Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

23 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression analysis of neuronal differentiation of HOXA6/HOXB6/UBE3A mutants cells

ABSTRACT: Transcriptome analysis of HOXA6, HOXB6 and UBE3A mutants during neuronal differentiation

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Shay Kinreich

PROVIDER: E-MTAB-13611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Expression analysis of neuronal differentiation of HOXA/B6 mutant cells

Project description:Transcriptome analysis of HOXB6 AND HOXA6 mutants during neuronal differentiation

2023-05-30 | E-MTAB-11943 | biostudies-arrayexpress

Expression analysis of neuronal differentiation of single mutants UBE3A/PHLDA2/SLC22A18 and double mutant PHLDA2/SLC22A18 cells

Project description:Transcriptome analysis of UBE3A, PHLDA2, SLC22A18 and PHLDA2/SLC22A18 mutants during neuronal differentiation

2024-04-30 | E-MTAB-12504 | biostudies-arrayexpress

CUT&RUN of HOXA6 and HOXB6 in neuronal-derived human embryonic stem cells

Project description:CUT&RUN analysis of HOXA6 and HOXB6 binding sites in neuronal-derived human embryonic stem cells

2024-04-30 | E-MTAB-13627 | biostudies-arrayexpress

Expression analysis of endoderm derived h-PES10 cells

Project description:Transcriptome of endoderm derived h-PES10 cells infected with empty lentivirus.

2023-08-09 | E-MTAB-13044 | biostudies-arrayexpress

RNA-seq of hESCs harboring imprinting-related genetic perturbations

Project description:To search for factors regulating paternally imprinted genes (PEGs), we performed a genome-wide CRISPR/Cas9 screen in haploid hpESCs, and further analyzed the molecular phenotype upon perturbation of candidate PEGs regulators.

2021-10-21 | E-MTAB-11012 | biostudies-arrayexpress

Ladostigil attenuates the oxidative and ER stress in human neuroblast-like SH-SY5Y cells

Project description:In this study, we investigate the impact of ladostigil on neuronal-like SH-SY5Y cells. As ladostigil may attenuate neurotoxicity and cell death that signify chronic stress conditions of an aging brain.

2022-07-25 | E-MTAB-10817 | biostudies-arrayexpress

Comparison of Hox6 mutant and control E12.5 mouse pancreas

Project description:Hox genes are critical developmental transcription factor. We found that in mice with disrupted expression of Hoxa6, Hoxb6 and Hoxc6 there is significantly disrupted endocrine pancreas development. We used microarray analysis to probe for possible molecular mechanisms involed in Hox6 signaling in pancreas development.

2015-04-30 | GSE68390 | GEO

Comparison of Hox6 mutant and control E12.5 mouse pancreas

2015-04-30 | E-GEOD-68390 | biostudies-arrayexpress

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids.

Project description:Angelman syndrome is a neurodevelopmental disorder caused by (epi)genetic lesions of maternal UBE3A. Research has focused largely on the role of UBE3A in neurons due to its imprinting in that cell type. Yet, evidence suggests there may be broader neurodevelopmental impacts of UBE3A dysregulation. Human cerebral organoids can investigate these understudied aspects of UBE3A as they recapitulate diverse cell types of the developing human brain. We performed single-cell RNA-sequencing on organoids to reveal the effects of UBE3A disruption on cell type-specific transcriptomic alterations and compositions. In the absence of UBE3A, progenitor proliferation and structures were disrupted while organoid composition shifted away from proliferative cell types. We observed impacts on non-neuronal cells including choroid plexus enrichment. Furthermore, EMX1+ cortical progenitors were negatively impacted, disrupting corticogenesis, and potentially delaying neuron maturation. This work reveals novel impacts of UBE3A on understudied cell types and related neurodevelopmental processes and elucidates potential new therapeutic targets.

2024-03-13 | GSE253230 | GEO

effects of ZMYM2 KO on gene expression of pluripotent and differentiating ESCs

Project description:RNA-seq of ZMYM2-null ESCs and derived teratomas

2020-06-19 | E-MTAB-8169 | biostudies-arrayexpress