Dataset Information
Effects of daf-2 mutation, dietary restriction and age on C.elegans proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: 
Vlad Petyuk
LAB HEAD: Vladislav Petyuk
PROVIDER: PXD002161 | Pride | 2015-05-13
REPOSITORIES: Pride
Publications
Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.
Molecular & cellular proteomics : MCP 20130903 12
Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of ribosomal subunits is decreased in response to dietary restriction, as well as in the da ...[more]
