Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-11046

ABSTRACT: Influences of Bowman-Birk Inhibitor on genomics in Drosophila melanogaster larval midguts

PROVIDER: E-GEOD-11046 | ExpressionAtlas | 2014-07-03

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-11046-analysis-methods.tsv	Tabular
	E-GEOD-11046-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-11046-configuration.xml	Xml
	E-GEOD-11046-percentile-ranks.tsv	Tabular
	E-GEOD-11046-zoomifications-log.tsv	Tabular

Items per page:

1 - 5 of 66

Similar Datasets

Drosophila melanogaster

Project description:Influences of Bwoman-Birk Inhibitor on genomics in Drosophila melanogaster larval midguts

| PRJNA107029 | ENA

Influences of Bowman-Birk Inhibitor on genomics in Drosophila melanogaster larval midguts

Project description:Bowman-Birk Inhibitor (BBI) has both insecticidal and anti-cancerous properties. It has been hypothesized that dietary BBI slows insect growth by inhibiting the catalytic activity of digestive enzymes trypsins and chyomotrypsins, resulting in the midgut having reduced access to amino acids needed for growth. In mammals, BBI was hypothesized to influence cellular energy metabolism. Thus, we tested the hypothesis that dietary BBI also impacts energy-associated pathways in the midgut of Drosophila melanogaster. We investigated the impact of dietary BBI on the following parameters in the midguts of third-instar Drosophila larvae: (i) cellular metabolites, (ii) global transcriptome response, (iii) putative transcription factor binding sites (TFBSs) associated with the differentially expressed transcripts, and (iv) epithelial cellular structure. Dietary BBI caused: (i) a reduction of cellular DHAP, glucose, and succinate; and, (ii) increased Fructuse-6-phosphate; (ii) differential expression of genes associated with the glucose and fatty acid utilization; and, (iii) a shortening of midgut epithelial microvilli, a phenomenon previously associated with glucose starvation. Additionally, fifty seven percent of the putative TFBSs associated with the differentially expressed transcripts have previously been associated with glucose and insulin activities in mammalian studies. Collectively these results support the hypothesis that dietary BBI influences energy utilization in the Drosophila midgut. Experiment Overall Design: Two treatments (control vs BBI-fed), and three replicates were conducted. There were total six samples. There was no dye-swap.

2008-10-26 | E-GEOD-11046 | biostudies-arrayexpress

Influences of Bwoman-Birk Inhibitor on genomics in Drosophila melanogaster larval midguts

2008-10-03 | GSE11046 | GEO

MTR_7g077160

Project description:Medicago truncatula MTR_7g077160, Bowman birk trypsin inhibitor, is differentially expressed in 2 experiment(s);

| MTR_7g077160 | ExpressionAtlas

MTR_7g077340

Project description:Medicago truncatula MTR_7g077340, Bowman birk trypsin inhibitor, is differentially expressed in 1 experiment(s);

| MTR_7g077340 | ExpressionAtlas

MTR_7g077215

Project description:Medicago truncatula MTR_7g077215, Bowman birk trypsin inhibitor, is differentially expressed in 2 experiment(s);

| MTR_7g077215 | ExpressionAtlas

MTR_7g077210

Project description:Medicago truncatula MTR_7g077210, Bowman birk trypsin inhibitor, is differentially expressed in 1 experiment(s);

| MTR_7g077210 | ExpressionAtlas

MTR_7g077180

Project description:Medicago truncatula MTR_7g077180, Bowman birk trypsin inhibitor, is differentially expressed in 3 experiment(s);

| MTR_7g077180 | ExpressionAtlas

MTR_7g077260

Project description:Medicago truncatula MTR_7g077260, Bowman birk trypsin inhibitor, is differentially expressed in 1 experiment(s);

| MTR_7g077260 | ExpressionAtlas

MTR_7g077300

Project description:Medicago truncatula MTR_7g077300, Bowman birk trypsin inhibitor, is differentially expressed in 1 experiment(s);

| MTR_7g077300 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data