Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-13396

ABSTRACT: Transcription profiling by array of cultured bronchial epithelial cells from patients with asthma and healthy individuals after infection with human rhinovirus

OTHER RELATED OMICS DATASETS IN: PRJNA109753

PROVIDER: E-GEOD-13396 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-13396-analysis-methods.tsv	Tabular
	E-GEOD-13396-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-13396-configuration.xml	Xml
	E-GEOD-13396-percentile-ranks.tsv	Tabular
	E-GEOD-13396.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 69

Similar Datasets

E-MTAB-4660

Project description:Transcription profiling of human blood eosinophils in eosinophilic asthma patients compared to healthy individuals

2025-01-23 | E-MTAB-4660 | ExpressionAtlas

E-GEOD-17400

Project description:Transcription profiling by array of human bronchial epithelial cells after infection with SARS-CoV and DOHV

2025-01-24 | E-GEOD-17400 | ExpressionAtlas

Expression data from airway epithelial cells from patients with asthma, rhinitis, and helathy controls

Project description:The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. We used micro array to profile gene expression of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. 17 subjects were included in a cross-sectional study (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls). RNA was extracted from isolated and cultured epithelial cells from bronchial brushes and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array).

2013-02-05 | E-GEOD-44037 | biostudies-arrayexpress

E-GEOD-63142

Project description:Transcription profiling by array of bronchial epithelial cells from severe asthmatic, mild-moderate asthmatic and non-asthmatic patients

2025-01-24 | E-GEOD-63142 | ExpressionAtlas

Expression data from airway epithelial cells stimulated with Poly(I:C) from patients with asthma, rhinitis, and healthy controls

Project description:Rhinovirus infections are the most common cause of asthma exacerbations. The complex responses by the airway epithelium to rhinovirus can be captured by gene expression profiling. We hypothesized that the upper and lower airway epithelium exhibit differential responses to double-stranded RNA (dsRNA), and that this is modulated by the presence of asthma and allergic rhinitis. Identification of dsRNA-induced gene expression profiles by microarray of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. 17 subjects were included in a cross-sectional study (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls). RNA was extracted from isolated and cultured epithelial cells that were stimulated with Poly(I:C) for 24 hours from bronchial brushes and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array).

2013-10-18 | E-GEOD-51392 | biostudies-arrayexpress

E-TABM-734

Project description:Transcription profiling by array of primary human macrophages cultured from patients with ulcerative colitis or healthy individuals with or without stimulation by heat-killed E. coli

2025-01-16 | E-TABM-734 | ExpressionAtlas

E-GEOD-34015

Project description:Transcription profiling by array of human CD34+ cells from bone marrow of patients with mucosa-associated lymphoid tissue (MLAT) lymphoma and control CD34+ cells from healthy individuals

2025-01-24 | E-GEOD-34015 | ExpressionAtlas

DNA methylation in airway epithelial cells isloated by pronase and bronchial brush from individuals with and without asthma

Project description:The airway epithelium forms the interface between the inhaled environment and the lung. The airway epithelium is dysfunctional in asthma and epigenetic mechanisms are considered a contributory factor. We hypothesised that the DNA methylation profiles of cultured primary airway epithelial cells (AECs) would differ between cells isolated from individuals with asthma (n=17) versus those without asthma (n=16). AECs were isolated from patients by two different isolation techniques; pronase digestion (9 non-asthmatic, 8 asthmatic) and bronchial brushings (7 non-asthmatic and 9 asthmatic). DNA methylation was assessed using an Illumina Infinium HumanMethylation450 BeadChip array. DNA methylation of AECs clustered by isolation technique and linear regression identified 111 CpG sites differentially methylated between isolation techniques in healthy individuals. As a consequence, the effect of asthmatic status on DNA methylation was assessed within AEC samples isolated using the same technique. In pronase isolated AECs, 15 DNA regions were differentially methylated between asthmatics and non-asthmatics. In bronchial brush isolated AECs, 849 differentially methylated DNA regions were identified with no overlap to pronase regions. In conclusion, regardless of cell isolation technique, differential DNA methylation was associated with asthmatic status in AECs, providing further evidence for aberrant DNA methylation as a signature of epithelial dysfunction in asthma.

2019-10-31 | GSE137716 | GEO

E-GEOD-32924

Project description:Transcription profiling by array of lesional and non-lesional skin from atopic dermatitis patients and healthy individuals

2025-01-24 | E-GEOD-32924 | ExpressionAtlas

E-TABM-127

Project description:Transcription profiling by array of human bronchial epithelial cells after exposure to cigarette smoke

2025-01-16 | E-TABM-127 | ExpressionAtlas