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E-GEOD-1615

ABSTRACT: Transcription profiling of human theca cells from women with polycystic ovary syndrome and normal theca cells treated with valproate

OTHER RELATED OMICS DATASETS IN: PRJNA90717

PROVIDER: E-GEOD-1615 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-1615-analysis-methods.tsv	Tabular
	E-GEOD-1615-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-1615-configuration.xml	Xml
	E-GEOD-1615-percentile-ranks.tsv	Tabular
	E-GEOD-1615.condensed-sdrf.tsv	Tabular

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Similar Datasets

Transcription profiling of human theca cells from women with polycystic ovary syndrome and normal theca cells treated with valproate

Project description:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. Interestingly, the anti-epileptic drug valproic acid induces increased theca cell androgen synthesis and increased CYP17 and CYP11A mRNA levels. In this study we have characterized the gene expression profiles of theca cells obtained from normal or polycystic ovaries which were maintained in the absence (UNT) or presence (VPA) of valproic acid. The data identifed new candidate genes and novel signaling pathways which may contribute to the manifestation of PCOS phenotypes including increased androgen production. The experiments in this study were carried using the Affymetrix U133A and U133B oligonucleotide chips.

2007-08-13 | E-GEOD-1615 | biostudies-arrayexpress

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Project description:Polycystic ovary Syndrome (PCOS) is a heterogeneous endocrine disorder that shows evidence of genetic predidposition among affected individuals. We have utilized the Microarray data from granulosa cells of normal and PCOS women for network construction. Human granulosa cells were isolated from ovarian aspirates from normal and PCOS women undergoing IVF and for each sample, RNA was extracted and hybridized to an Affymetrix GeneChip.

2012-11-06 | E-GEOD-34526 | biostudies-arrayexpress

Theca cell gene expression

2005-01-04 | GSE1615 | GEO

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

2012-11-06 | GSE34526 | GEO

E-MTAB-1027

Project description:Transcription profiling by array of normal human bronchial epithelial cells treated with tumor necrosis factor-alpha

2025-01-23 | E-MTAB-1027 | ExpressionAtlas

E-GEOD-51415

Project description:Transcription profiling by high throughput sequencing of retinoic acid treated human oral squamous cell carcinoma cells and normal cells

2025-01-24 | E-GEOD-51415 | ExpressionAtlas

Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone

Project description:Prenatal testosterone treated sheep, similar to PCOS women, manifest reduced cyclicity, functional hyperandrogenism and polycystic ovary (PCO) morphology. The PCO morphology results from increased follicular recruitment and persistence of antral follicles, consequence of reduced follicular growth and atresia, and driven by cell-specific gene expression changes that are poorly understood. Therefore, utilizing RNA sequencing, cell-specific transcriptional changes were assessed in laser capture microdissection isolated antral follicular granulosa and theca cells from 21 months-of- age control and prenatal testosterone treated sheep.

2020-06-18 | GSE150236 | GEO

E-GEOD-13987

Project description:Transcription profiling of human B lineage chronic lymphocytic leukemia, normal B, and normal T cells treated with rolipram, a PDE4 inhibitor

2025-01-24 | E-GEOD-13987 | ExpressionAtlas

Peptidomic analysis of follicular fluid in patients with polycystic ovarian syndrome

Project description:The aim of this study was to analyze and compare the differential expression of peptides within the follicular fluid of polycystic ovary syndrome (PCOS) patients versus normal women by using peptidomics techniques. The underlying mechanisms involved in PCOS pathogenesis will be explored, together with screening and identification of potential functional peptides via bioinformatics analysis.

2023-10-27 | PXD045753 | Pride

Identification of microRNA profiling of human ovary in PCOS with insulin resistance (pilot study)

Project description:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It has become increasingly evident that insulin resistance plays a significant role both as a cause and result of the syndrome. In an effort to investigate further the observed insulin resistance in the ovarian tissue of women with PCOS, we conducted array-based, global miRNA profiling.

2015-01-12 | GSE28832 | GEO

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