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E-GEOD-19278

ABSTRACT: S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133_Plus_2]

OTHER RELATED OMICS DATASETS IN: PRJNA123889PRJNA123893PRJNA123891

PROVIDER: E-GEOD-19278 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-19278-analysis-methods.tsv	Tabular
	E-GEOD-19278-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-19278-configuration.xml	Xml
	E-GEOD-19278-percentile-ranks.tsv	Tabular
	E-GEOD-19278.condensed-sdrf.tsv	Tabular

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Project description:S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133A]

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Project description:S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133B]

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E-GEOD-37911

Project description:VEGF189 overexpression in breast cancer cells delays metastasis

2025-01-24 | E-GEOD-37911 | ExpressionAtlas

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133_Plus_2]

Project description:We and others have shown that S100P is highly upregulated during the progression of pancreatic cancer. We used microarrays to look at the target genes regulated by S100P in the pancreatic cancer cell line Panc1. Keywords: Gene overexpression We generated stable cell lines by introducing control vector pcDNA3.1/V5-His or S100P-overexpressing vector pcDNA3.1/S100P-V5-His into the pancreatic cancer cell line Panc1, single cell clones were then isolated. RNA was extracted and hybridized on Affymetrix microarrays. We looked for new target genes regulated by S100P.

2013-08-15 | E-GEOD-19278 | biostudies-arrayexpress

E-GEOD-35198

Project description:Transcriptional profiling comparing S100PBP over-expressing human FA6 pancreatic cancer cells to vector-only control FA6 cells

2025-01-24 | E-GEOD-35198 | ExpressionAtlas

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133_Plus_2]

2013-08-15 | GSE19278 | GEO

The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

Project description:The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several experimental models for the disease. We show here that QN-302 also causes down-regulation of the expression of the S100P gene and the S100P protein in cells and in vivo. This protein is well-established as being involved in key proliferation and motility pathways in several human cancers and has been identified as a potential biomarker in pancreatic cancer. The S100P gene contains 60 putative quadruplex-forming sequences, one of which is in the promoter region, 48 nucleotides up-stream from the transcription start site. We report biophysical and molecular modeling studies showing that this sequence forms a highly stable G-quadruplex in vitro, which is further stabilized by QN-302. We also report transcriptome analyses showing that S100P expression is highly upregulated in tissues from human pancreatic cancer tumors, compared to normal pancreas material. The extent of up-regulation is dependent on the degree of differentiation of tumor cells, with the most poorly differentiated, from more advanced disease, having the highest level of S100P expression. The experimental drug QN-302 is currently in pre-IND development (as of Q1 2023) and its ability to down-regulate S100P protein expression supports a role for this protein as a marker of therapeutic response in pancreatic cancer. These results are also consistent with the hypothesis that the S100P promoter G-quadruplex is a potential therapeutic target in pancreatic cancer at the transcriptional level for QN-302.

2023-04-01 | GSE226307 | GEO

E-GEOD-16082

Project description:Networking of differentially expressed genes in human MIA PaCa2 pancreatic cancer cells resistant to methotrexate

2025-01-24 | E-GEOD-16082 | ExpressionAtlas