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E-GEOD-24978

ABSTRACT: Transcription profiling by array of Drosophila larval eye discs mutant for rbs and/or wts

OTHER RELATED OMICS DATASETS IN: PRJNA131911

PROVIDER: E-GEOD-24978 | ExpressionAtlas | 2014-09-05

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-24978-analysis-methods.tsv	Tabular
	E-GEOD-24978-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-24978-configuration.xml	Xml
	E-GEOD-24978-percentile-ranks.tsv	Tabular
	E-GEOD-24978.condensed-sdrf.tsv	Tabular

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Project description:PSC overexpression can cause phenotypes specifically in an rbf1 mutant background, likely due to a sensitization to PSC-induced phenotypes. The goal of this study is to understand the interaction between rbf1 hypomorphic mutation and the overexpression of Polycomb group gene Posterior sex combs. We used Drosophila larval eye imaginal discs that were mutant for rbf1 or overexpressing PSC and compared these to control larval eye discs to assess changes in gene expression. We identified a common set of genes that are deregulated when rbf1 is mutated or when PSC is overexpressed. RNA was extracted from eye imaginal discs dissected from third instar Drosophila larvae. Samples were amplified and hybridized to Affymetrix Drosophila Genome 2.0 Array. To better understand the effects of rbf1 mutation and PSC overexpression, we compared the gene expression of rbf1 mutant eye discs and eye discs overexpressing PSC to control eye discs.

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2022-11-19 | GSE211458 | GEO

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