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E-GEOD-34248

ABSTRACT: Gene expression profiling in psoriatic lesional and non-lesional skin [Set 1]

OTHER RELATED OMICS DATASETS IN: PRJNA177850PRJNA149759PRJNA177848PRJNA177849

PROVIDER: E-GEOD-34248 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-34248-analysis-methods.tsv	Tabular
	E-GEOD-34248-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-34248-configuration.xml	Xml
	E-GEOD-34248-percentile-ranks.tsv	Tabular
	E-GEOD-34248.condensed-sdrf.tsv	Tabular

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Project description:In this study, we sought to establish the usefulness of LCM on cDNA microarray analysis. We reported that LCM samples improved the sensitivity of detection of differentially expressed genes over conventional bulk tissue analysis. We also provided the new information of chemokine and its receptor interaction within psoriatic lesional skin. For the comparison of gene expression patterns between single and double amplification techniques, total RNA was extracted from blocks of paired lesional and non-lesional psoriatic skin biopsies from four patients. For LCM experiment, total RNA was extracted from sliced tissue sections of paired lesional and non-lesional psoriatic skin biopsies from three patients.

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