Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-37258

ABSTRACT: Expression data of the iPSCs derived from foreskin fibroblast cells of normal person and KS patient

OTHER RELATED OMICS DATASETS IN: PRJNA159231

PROVIDER: E-GEOD-37258 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-37258-analysis-methods.tsv	Tabular
	E-GEOD-37258-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-37258-configuration.xml	Xml
	E-GEOD-37258-percentile-ranks.tsv	Tabular
	E-GEOD-37258.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 96

Similar Datasets

Homo sapiens

Project description:Expression data of the iPSCs derived from foreskin fibroblast cells of normal person and KS patient

| PRJNA159231 | ENA

Exon Level Expression Profiling: a Novel Unbiased Transcriptome

Project description:Transcriptome analysis of the effect of RECTAS on fibroblast cells derived from a familial dysautonomia patient. We analyzed fibroblast derived from FD patient (3 control (treated with 0.1% DMSO) and 3 treated (treated with 2 M-BM-5M RECTAS)) using the Affymetrix Human Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No techinical replicates were performed.

2015-01-31 | E-GEOD-58038 | biostudies-arrayexpress

Expression data from germ cell tumor patient-derived cells

Project description:Expression data from germ cell tumor patient-derived cells

| PRJNA527840 | ENA

Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model

Project description:Patient derived organoids (PDOs) have been established as a 3D culture model which closely recapitulates the in vivo tumor biology. However, one limitation of this culture model is the lack of tumor microenvironment which has a significant role in tumor progression and drug response. To address this, we established and molecularly characterized a novel 3D co-culture model of colorectal cancer (CRC) based on PDOs and patient matched fibroblasts. Both normal and cancer associated fibroblasts, NFs and CAFs respectively, were able to support organoid growth without addition of niche factors to the media. Additionally, co-cultures showed closer resemblance to primary patient material than organoid mono-cultures as evaluated by histology. Finally, RNA gene expression signatures of tumor cells and fibroblasts isolated from mono- or co-cultures demonstrated that co-cultures support greater cell type heterogeneity. In this proteomics dataset we compared pairs of NFs and CAFs derived from five patients. Collectively, we present a newly established human derived organoid-fibroblast model which, closely recapitulates in vivo tumor heterogeneity and involves the tumor microenvironment.

2023-03-14 | PXD032047 | Pride

Expression data of the iPSCs derived from foreskin fibroblast cells of normal person and KS patient

Project description:Klinefelter’s Syndrome (KS) is one of the common chromosome aneuploidy diseases in males with unexplained physiological mechanism. iPSCs, are similar to ESCs in terms of indefinitive self-renewal and pluripotency, provided an alternative choice for modeling disease to facilitate the disease research in vitro. We used microarray to detect the global reprogramming of KS and normal fibroblast cells to iPSCs. Also we used microarray to explore the possible molecular varieties between KS patient and normal person in the early development. Fibroblast cells from both normal person and KS patient were reprogrammed into iPSCs by ectopic expression of OCT4, SOX2, KLF4 and C-MYC. The expression profiles of normal and KS fibroblast cells, a line of normal iPSCs and two lines of KS iPSCs as well as a line of human ESCs were detected.

2012-04-13 | E-GEOD-37258 | biostudies-arrayexpress

Gene expression data from endometrial cancer patient-derived cells (PDCs)

Project description:Gene expression data from endometrial cancer patient-derived cells (PDCs)

| PRJNA524388 | ENA

Effects of urinary extracellular vesicles from prostate cancer patients on the transcriptomes of cancer-associated and normal fibroblasts

Project description:Patient-derived prostate fibroblast primary cultures PCF-54 and PCF-55 were established from two specimens of PC tissues. EVs were isolated from urine samples of 3 patients with PC and 2 healthy males and used for the treatment of prostate fibroblast primary cultures and normal foreskin fibroblasts. The EV-treated fibroblasts were subjected to RNA sequencing analysis.

2023-04-01 | E-MTAB-11022 | biostudies-arrayexpress

Expression data from CRC patient-derived organoids

Project description:Expression data from CRC patient-derived organoids

| PRJNA526815 | ENA

Gene expression data from metastatic endometrial cancer patient-derived cells (PDCs)

Project description:Gene expression data from metastatic endometrial cancer patient-derived cells (PDCs)

| PRJNA524385 | ENA

Exon Level Expression Profiling: a Novel Unbiased Transcriptome

Project description:Transcriptome analysis of the effect of RECTAS on fibroblast cells derived from a familial dysautonomia patient.

2015-01-31 | GSE58038 | GEO