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E-GEOD-39803

ABSTRACT: Transcription profiling by array of mouse bone marrow cells transfected with miR 142-3p mimic oligo

OTHER RELATED OMICS DATASETS IN: PRJNA171744PRJNA171837

PROVIDER: E-GEOD-39803 | ExpressionAtlas | 2015-11-05

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-39803-analysis-methods.tsv	Tabular
	E-GEOD-39803-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-39803-configuration.xml	Xml
	E-GEOD-39803-percentile-ranks.tsv	Tabular
	E-GEOD-39803.condensed-sdrf.tsv	Tabular

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E-MTAB-6594

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Project description:Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

| PRJNA171744 | ENA

Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

Project description:Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describe that miR-142-3p down-regulation directs macrophage differentiation and determines the acquisition of their immunosuppressive function in cancer. Enforced miR over-expression impaired monocyte to macrophage transition both in vitro and in vivo. Conversely, forced miR down-regulation promoted the generation of immunosuppressive macrophages even during G-CSF-induced granulocytic differentiation. To identify how miR-142-3p regulates MDSC generation and activity, we analyze the gene expression of BM cultures transfected with either CTRL- or miR 142-3p mimic oligo -transfected before four days GM-CSF and IL-6 treatment. Keywords: Expression profiling by array

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Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress

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Project description:Transcription profiling by array of mouse bone marrow derived eosinophils mutant for miR-223

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Project description:RNA-Seq analysis of MCV-miR-M1 mimic-transfected HEK293 cells

2025-01-23 | E-MTAB-6526 | ExpressionAtlas

Differential gene regulation by miR-142-3p and miR-K10a isomiRs

Project description:This study compares changes in gene expression induced by four interrelated miRNAs with similar but staggered 5'-ends: miR-142-3p, miR-142-3p-1, miR-K10a, and miR-K10a+1. miR-K10a and miR-K10a+1 are co-expressed by the Kaposi's sarcoma-associated herpesvirus. Total RNA was harvested from HEK293 cells transfected with individual miRNAs including a negative control miRNA mimic.

2015-07-31 | E-GEOD-66489 | biostudies-arrayexpress

miR-142-3p over-expression in the Raji B-cell line

Project description:miR-142-3p is highly expressed in peripheral blood mononuclear cells (PBMCs) and has been described as a hematopoietic-restricted lineage, suggesting immune functions (Chen, Li et al. 2004; Landgraf, Rusu et al. 2007; Merkerova, Belickova et al. 2008). In order to determine the roles of miR-142-3p in B lymphocytes, we over-expressed this miRNA in the Raji B-cell line using a synthetic mimic of miR-142-3p and analyzed gene expression 24 hours after the transfection. Four replicates each of miR-142-3p-mimic transfection and apparied control mimic.

2011-05-30 | E-GEOD-28456 | biostudies-arrayexpress

mRNA microarray analysis of uveal melanoma cell lines SP6.5 and M17 transfected with miR-142-3p or negative control

Project description:MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs of about 22 nt in length. Uveal melanoma is the most common intraocular malignant tumor in adults. Our previous result of microarray analysis showed that miR-142-3p was distinctly downregulated in uveal melanoma cells on which miR-142-3p was speculated to have important regulatory effect. In order to better understand the function of miR-142-3p in uveal melanoma and identify its gene targets, we performed transcriptomic microarray analysis. This was done by comparing gene expression profile changes in uveal melanoma cells transfected with miR-142-3p with that transfected with a negative control.

2019-02-28 | E-MTAB-6725 | biostudies-arrayexpress

Effect of overexpression of miR-210-3p on gene expression of human umbilical vein endothelial cells in hypoxic conditions

Project description:To investigate machanism of miR-210-3p regulating angiogenic ability of human umbilical vein endothelial cells (HUVECs) in hypoxic conditions, we transfected miR-210-3p mimic to overexpress miR-210-3p in human umbilical vein endothelial cells. We than performed RNA sequencing of miR-210-3p mimic-transfected and control HUVECs under hypoxic conditions to evaluate the transcriptional changes in the miR-210-3p-overexpressing HUVECs.

2022-09-28 | GSE214170 | GEO

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