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E-GEOD-39803

ABSTRACT: Transcription profiling by array of mouse bone marrow cells transfected with miR 142-3p mimic oligo

OTHER RELATED OMICS DATASETS IN: PRJNA171744PRJNA171837

PROVIDER: E-GEOD-39803 | ExpressionAtlas | 2015-11-05

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-39803-analysis-methods.tsv	Tabular
	E-GEOD-39803-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-39803-configuration.xml	Xml
	E-GEOD-39803-percentile-ranks.tsv	Tabular
	E-GEOD-39803.condensed-sdrf.tsv	Tabular

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Project description:Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

| PRJNA171744 | ENA

Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

Project description:Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describe that miR-142-3p down-regulation directs macrophage differentiation and determines the acquisition of their immunosuppressive function in cancer. Enforced miR over-expression impaired monocyte to macrophage transition both in vitro and in vivo. Conversely, forced miR down-regulation promoted the generation of immunosuppressive macrophages even during G-CSF-induced granulocytic differentiation. To identify how miR-142-3p regulates MDSC generation and activity, we analyze the gene expression of BM cultures transfected with either CTRL- or miR 142-3p mimic oligo -transfected before four days GM-CSF and IL-6 treatment. Keywords: Expression profiling by array

2015-07-23 | GSE39803 | GEO

Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress

Effect of overexpression of miR-210-3p on gene expression of human umbilical vein endothelial cells in hypoxic conditions

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microRNA array of SH-SY5Y cells

Project description:This experiment captures expression over 60,000 well-annotated RefSeq human transcripts over RNA samples from SH-SY5Y neuroblastoma cells transfected with human and non-human primate microRNA mimic variants of miR-299-3p, miR-503-3p, miR-508-3p and miR-541-3p, as well as a RNA duplex negative control (C2 mimic, Dharmacon).

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Effect of overexpression of miR-423-5p on gene expression of endothelial cells.

Project description:To investigate machanism of miR-423-5p regulating the angiogenic ability of bEnd.3 cells, we transfected miR-423-5p mimic to overexpress miR-423-5p in bEnd.3 cells. Then we performed high throughput sequencing of miR-423-5p mimic-transfected and control bEnd.3 cells to evaluate different gene expressions between miR-210-3p-overexpressing and control.

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Project description:We intended to investigate effects of mmu-miR-15a-3p on gene expression in mice We used microarrays to compare gene expression in mouse B/CMBA.Ov cell lines transfected with mmu-miR-15a-3p and negative control mimic

2013-01-01 | E-GEOD-42797 | biostudies-arrayexpress

Comparison of gene expression between MIA PaCa-2 cells transfected with miR-4653-3p mimic and negative control cells

Project description:To identify the target of miR-4653-3p, mRNA microarray analysis was performed to compare mRNA expression between MIA PaCa-2 cells transfected with miR-4653-3p mimic and negative control cells.

2023-05-28 | E-MTAB-11813 | biostudies-arrayexpress

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