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E-GEOD-40885

ABSTRACT: Data expression in alveolar macrophages induced by lipopolysaccharide in humans

OTHER RELATED OMICS DATASETS IN: PRJNA175261

PROVIDER: E-GEOD-40885 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-40885-analysis-methods.tsv	Tabular
	E-GEOD-40885-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-40885-configuration.xml	Xml
	E-GEOD-40885-percentile-ranks.tsv	Tabular
	E-GEOD-40885.condensed-sdrf.tsv	Tabular

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Project description:Data expression in alveolar macrophages induced by lipopolysaccharide in humans

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Data expression in alveolar macrophages induced by lipopolysaccharide in humans

Project description:Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes exposed to inhaled antigens. Objectives: To obtain insight into which innate immune pathways become activated within human alveolar macrophages upon exposure to LPS in vivo. In seven healthy humans sterile saline was instilled into a lung segment by bronchoscope, followed by instillation of LPS into the contralateral lung. Six hours later a bilateral bronchoalveolar lavage was performed and whole-genome transcriptional profiling was done (Affymetrix HG-U133 Plus 2.0) on purified alveolar macrophages, comparing cells exposed to saline or LPS from the same individuals.

2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress

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