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E-GEOD-42768

ABSTRACT: Transcription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis

OTHER RELATED OMICS DATASETS IN: PRJNA183090

PROVIDER: E-GEOD-42768 | ExpressionAtlas | 2014-10-17

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-42768-analysis-methods.tsv	Tabular
	E-GEOD-42768-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-42768-configuration.xml	Xml
	E-GEOD-42768-percentile-ranks.tsv	Tabular
	E-GEOD-42768.condensed-sdrf.tsv	Tabular

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Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

Project description:The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphate (DSS) to mimic the relapsing nature of the disease. We used whole gene expression arrays to study differences in colonic gene expression levels between acute and more chronic DSS colitis, Acute and chronic relapsing colonic inflammation was induced in C57BL6 female mice using several cycles of exposure to DSS in drinking water, followed by recovery phases. Total RNA, extracted from snap frozen colon from five mice per condition was used to analyze mRNA expression via Affymetrix Mouse Gene 1.0 ST arrays.

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Project description:Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

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Project description:Transcription profiling by array of colon epithelial cells from mice expressing transgenic claudin-2 and wild type controls with or without dextran sodium sulfate (DSS)-induced colitis

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