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E-GEOD-5390

ABSTRACT: Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

OTHER RELATED OMICS DATASETS IN: PRJNA96183

PROVIDER: E-GEOD-5390 | ExpressionAtlas | 2015-07-27

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-5390-analysis-methods.tsv	Tabular
	E-GEOD-5390-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-5390-configuration.xml	Xml
	E-GEOD-5390-percentile-ranks.tsv	Tabular
	E-GEOD-5390.condensed-sdrf.tsv	Tabular

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Similar Datasets

Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

Project description:Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Experiment Overall Design: RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.

2009-04-23 | E-GEOD-5390 | biostudies-arrayexpress

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Project description:Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

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Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

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Project description:Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

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Transcription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

Project description:This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Experiment Overall Design: Refer to individual Series

2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress

DNA methylation profiles of human blood samples from a severe developmental disorder and controls

Project description:Human DNA methylation Beadchip v1.2 was used to obtain n=113 Illumina DNA methylation array from whole blood samples. The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of subjects with a severe developmental disorder (known as syndrome X) and controls. To measure DNA methylation age, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928. The data set contains 5 affected female subjects who exhibit a pure form of syndrome X. Further, the study includes two syndrome X-like subjects who also have Down syndrome and Ring- X Turner syndrome, respectively. For the diseased subjects, we collected several family members (parents and possibly siblings). We also collected several control families who do not have an affected child. Apart from family data, we also analyzed 62 blood samples from healthy controls.

2015-05-28 | E-GEOD-64495 | biostudies-arrayexpress

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Project description:Adult postmortem brain tissue (orbitofrontal cortex) from subjects with bipolar disorder and healthy controls

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2008-06-17 | E-GEOD-8507 | biostudies-arrayexpress

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