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E-GEOD-5390

ABSTRACT: Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

OTHER RELATED OMICS DATASETS IN: PRJNA96183

PROVIDER: E-GEOD-5390 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-5390-analysis-methods.tsv	Tabular
	E-GEOD-5390-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-5390-configuration.xml	Xml
	E-GEOD-5390-percentile-ranks.tsv	Tabular
	E-GEOD-5390.condensed-sdrf.tsv	Tabular

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Project description:Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Experiment Overall Design: RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.

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