Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-54112

ABSTRACT: ZNF804A transcriptome networks in differentiating human neurons derived from induced pluripotent stem cells

OTHER RELATED OMICS DATASETS IN: PRJNA235198

PROVIDER: E-GEOD-54112 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-54112-analysis-methods.tsv	Tabular
	E-GEOD-54112-analytics.tsv	Tabular
	E-GEOD-54112-analytics.tsv.undecorated	Tabular
	E-GEOD-54112-analytics.tsv.undecorated.unrounded	Tabular
	E-GEOD-54112-analytics.tsv.unrounded	Tabular

Items per page:

1 - 5 of 33

Similar Datasets

Homo sapiens

Project description:ZNF804A transcriptome networks in differentiating human neurons derived from induced pluripotent stem cells

| PRJNA235198 | ENA

E-MTAB-7938

Project description:RNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells

2025-01-23 | E-MTAB-7938 | ExpressionAtlas

E-MTAB-3158

Project description:Transcriptional Profiling of human pluripotent stem cells and and derived tissues

2025-01-23 | E-MTAB-3158 | ExpressionAtlas

E-MTAB-7000

Project description:Epithelium-only cultured stem cells isolated from human pluripotent stem cell derived intestinal organoids grown in matrigel and alginate

2025-01-23 | E-MTAB-7000 | ExpressionAtlas

E-GEOD-75852

Project description:Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks

2025-01-24 | E-GEOD-75852 | ExpressionAtlas

E-GEOD-71289

Project description:Transcriptome profiling of human neural progenitor cells and neurons with DISC1 interruption

2025-01-24 | E-GEOD-71289 | ExpressionAtlas

E-MTAB-5958

Project description:RNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development

2025-01-23 | E-MTAB-5958 | ExpressionAtlas

Metabolites of human neurons and stem cells (siNeuron metabolomics)

Project description:There are a total of four samples each for this analysis. Each sample consists of the cells grown on three 10 cm culture plates. Each plate should have 2x106 cells for a total of 6x106 cells per sample when all three plates are combined. The first sample is undifferentiated human embryonic stem cells, the second sample is human glutamatergic neurons derived from those human embryonic stem cells, the third sample is undifferentiated human induced pluripotent stem cells and the fourth sample is human glutamatergic neurons derived from those human induced pluripotent stem cells.

2017-06-19 | ST000768 | MetabolomicsWorkbench

RNA-Seq of human neurons derived from iPS cells Reveals candidate long non-coding RNAs Involved in neurogenesis and neuropsychiatric disorders.

Project description:As a preliminary step towards applying next generation sequencing using neurons derived from patient-specific iPSCs, we have carried out an RNA-Seq analysis on control human neurons. Dramatic changes in the expression of coding genes, long non-coding RNAs (lncRNAs), pseudogenes, and splice isoforms were seen during the transition from pluripotent stem cells to early differentiating neurons. A number of genes that undergo radical changes in expression during this transition include candidates for schizophrenia (SZ), bipolar disorder (BD) and autism spectrum disorders (ASD) that function as transcription factors and chromatin modifiers, such as POU3F2 and ZNF804A, and genes coding for cell adhesion proteins implicated in these conditions including NRXN1 and NLGN1. In addition, a number of novel lncRNAs were found to undergo dramatic changes in expression, one of which is HOTAIRM1, a regulator of several HOXA genes during myelopoiesis. The increase we observed in differentiating neurons suggests a role in neurogenesis as well. Finally, several lncRNAs that map near SNPs associated with SZ in genome wide association studies also increase during neuronal differentiation, suggesting that these novel transcripts may be abnormally regulated in a subgroup of patients. Total RNAs were isolated from both iPS cells and differentiating neurons, and the sequenced material was pre-amplified using the NuGen Ovation amplification system. RNA-Seq libraries were prepared and carried out on Illumina HiSeq200.

2011-10-06 | E-GEOD-32625 | biostudies-arrayexpress

ZNF804A transcriptome networks in differentiating human neurons derived from induced pluripotent stem cells

Project description:The goal of this project is to study transcriptome change by knocking down ZNF804A, a schizophrenia and bipolar disorder candidate gene, in early neurons derived from iPSCs. Neural progenitor cells (NPCs) were developed from human induced pluripotent stem cells (iPSCs) and transduced by two independent shRNA vectors targeting ZNF804A, a schizophrenia and bipolar disorder candidate gene. After recovery and selection in puromycin, neuronal differentiation was induced. After 14 days, RNA was recovered and analyzed by RNA-seq. The expression profiles were compared with NPCs that were transduced with scrambled control vectors. This corresponds to controls 1-3 and KD 1-3, which was carried out on a male iPSC line. Scramble 1 and 2 and KD1 and 2 are technical replicates. Scrambled 3 and KD 3 were carried out on an independent NPC culture. For control 4 and KD4, neuronal differentiation was induced, and on day 10 the cells were transduced with the same ZNF804A KD and scrambled control vectors used for scrambled control 3 and KD3. In addition, this last set was carried out on a female iPSC line

2014-07-01 | E-GEOD-54112 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data