Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-54846

ABSTRACT: RNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts

OTHER RELATED OMICS DATASETS IN: PRJNA237811PRJNA237805PRJNA237809

PROVIDER: E-GEOD-54846 | ExpressionAtlas | 2019-05-14

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-54846-analysis-methods.tsv	Tabular
	E-GEOD-54846-analytics.tsv	Tabular
	E-GEOD-54846-analytics.tsv.undecorated	Tabular
	E-GEOD-54846-analytics.tsv.undecorated.unrounded	Tabular
	E-GEOD-54846-analytics.tsv.unrounded	Tabular

Items per page:

1 - 5 of 33

Similar Datasets

Homo sapiens

Project description:RNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts

| PRJNA237809 | ENA

polyA mRNA RNA-seq from IMR-90 (ENCSR000CTP)

Project description:The libraries contained in this experiment come from lung fibroblasts primary nuclear extracts, IMR90. They are stranded PE101 Illumina Hi-Seq RNA-Seq libraries from rRNA-depleted Poly-A+ RNA > 200 nucleotides in size. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2016-12-07 | GSE90262 | GEO

Project description:RNA-seq data of TFPI2-depleted human dermal fibroblasts

| PRJNA1200221 | ENA

Project description:RNA-seq data of FTO-depleted human dermal fibroblasts

| PRJNA1199897 | ENA

Homo sapiens

Project description:MacroH2A1 ChIP-seq from IMR90 human primary lung fibroblasts

| PRJNA237811 | ENA

4359ad73-f057-4bda-90e3-e8185e963dc8 - samples

Project description:Primary lung fibroblast were isolated from well-matched control donors (no COPD, n=3) and patients with COPD (GOLD stage I-IV, n=8). Total RNA of cultured human lung fibroblast were isolated at passage 3 and rRNA was depleted. 75 bp single-end reads were generated from RNA libraries on Illumina NextSeq 500.

| EGAD00001009405 | EGA

02f67634-f14b-4780-83ed-9f832a2aae51 - samples

Project description:Bulk RNA seq data from human lung fibroblasts isolated from fresh and cryopreserved lung tissue (18 samples, 3 donors)

| EGAD00001010252 | EGA

Arginine promotes the activation of lung fibroblasts independent of its metabolism

Project description:We investigated TGF-beta-induced gene expression in normal human lung fibroblasts (NHLFs) under different media setting, and diffrenece in TGF-beta-induced gene expression between control human male fibroblasts and human male IPF fibroblasts cultured in HPLM using RNA-seq.

2024-12-12 | GSE273882 | GEO

Transcriptomic changes induced by IL33 transduction, ST2 gene knockout, and their combination in primary mouse lung fibroblasts and unseparated mouse lung cells

Project description:RNA-Seq of unseparated lung cells and primary mouse lung fibroblasts from wild-type and ST2 gene knockout mice

2023-01-04 | GSE197398 | GEO

Bi-directional epithelial-mesenchymal crosstalk provides self-sustaining pro-fibrotic signals in pulmonary fibrosis

Project description:Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a median survival of 2-4 years. Injury to and/or dysfunction of alveolar epithelium are strongly implicated in IPF disease initiation, but what factors determine why fibrosis progresses rather than normal tissue repair occurs remain poorly understood. We previously demonstrated that ZEB1-mediated epithelial-mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells augments TGF-β-induced profibrogenic responses in underlying lung fibroblasts by paracrine signalling. Here we investigated bi-directional epithelial-mesenchymal crosstalk and its potential to drive fibrosis progression. RNA sequencing (RNA-seq) of lung fibroblasts exposed to conditioned media from ATII cells undergoing RAS-induced EMT identified many differentially expressed genes including those involved in cell migration and extracellular matrix (ECM) regulation. We confirmed that paracrine signalling between AS-activated ATII cells and fibroblasts augmented fibroblast recruitment and demonstrated that this involved a ZEB1-tissue plasminogen activator (tPA) axis. In a reciprocal fashion, paracrine signalling from TGF-β-activated lung fibroblasts or IPF fibroblasts induced RAS activation in ATII cells, at least partially via the secreted protein, SPARC. Together these data identify that aberrant bi-directional epithelial-mesenchymal crosstalk in IPF drives a chronic feedback loop that maintains a wound-healing phenotype and provides self-sustaining pro-fibrotic signals.

2021-08-19 | PXD025821 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data