Project description:The underlying molecular mechanisms in osteoarthritis (OA) development are largely unknown. This study explores the proteome and the pairwise interplay of proteins on a global level in synovial fluid from patients with late-stage knee OA (arthroplasty), early knee OA (arthroscopy due to degenerative meniscal tear) and from deceased controls without knee OA. Synovial fluid samples were analyzed using state-of-the-art mass spectrometry with data-independent acquisition. The differential expression of the proteins detected was clustered and evaluated with data mining strategies and a multilevel model. Group-specific slopes of associations were estimated between expressions of each pair of identified proteins to assess the co-expression (i.e. interplay) between the proteins in each group. More proteins were increased in early-OA vs controls than late-stage OA vs controls. For most of these proteins, the fold changes between late-stage OA vs controls and early stage OA vs controls were remarkably similar suggesting potential involvement in the OA process. Further, for the first time this study illustrated distinct patterns in protein co-expression suggesting that the global interplay between the protein machinery is increased in early-OA and lost in late-stage OA. Further efforts should probably focus on earlier stages of the disease than previously considered.

2022-01-27 | PXD023708 | Pride

Rattus norvegicus

Project description:Cardiopulmonary bypass (CPB) vs sham-operated controls

| PRJNA87947 | ENA

Dementia Comparison: VaD vs. AD vs. Controls

Project description:Dementia Comparison: VaD vs. AD vs. Controls

| PRJNA503386 | ENA

Transcriptome profile of ENDOC-BH1 cells overexpressing TFEB-V5 or controls

Project description:To analyse gene expression differences between the TFEB overexpressing cells vs. Controls, under growing conditions (GC) vs. Fasting conditions (Fast).

2023-07-31 | GSE154059 | GEO

Transcriptome profile of INS-1E Ctrl and hTFEB OE cells

Project description:To analyse gene expression differences between the human TFEB overexpressing cells vs. Controls, under growing conditions (GC) vs. Fasting conditions (Fast)

2023-07-31 | GSE155221 | GEO

Transcriptome profile of INS-1E Ctrl and DKO cells

Project description:To analyse gene expression differences between the TFEB/TFE3 KO cells vs. Controls, under growing conditions (GC) vs. Fasting conditions (Fast)

2023-07-31 | GSE153709 | GEO

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