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E-GEOD-74000

ABSTRACT: Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

OTHER RELATED OMICS DATASETS IN: PRJNA298696

PROVIDER: E-GEOD-74000 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-74000-analysis-methods.tsv	Tabular
	E-GEOD-74000-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-74000-configuration.xml	Xml
	E-GEOD-74000-percentile-ranks.tsv	Tabular
	E-GEOD-74000.condensed-sdrf.tsv	Tabular

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Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

Project description:In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated in vitro systems are: HepaRG cells, HepG2 cells and a novel human skinpostnatal stem cell-derived model i.e. human skin-precursors-derived hepatocyte-like cells (hSKP-HPC). Clinical samples were obtained after surgical removal of the explant liver of patients diagnosed with ALF due to acetaminophen intoxication and treated by orthotopic liver transplantation (n=3). Samples from healthy livers were obtained from individuals deceased from brain damage (n=2).

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