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E-GEOD-78701

ABSTRACT: Transcription profiling by high throughput sequencing of uterine-specific Tsc2-null mice

OTHER RELATED OMICS DATASETS IN: PRJNA313264

PROVIDER: E-GEOD-78701 | ExpressionAtlas | 2019-05-14

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-78701-analysis-methods.tsv	Tabular
	E-GEOD-78701-analytics.tsv	Tabular
	E-GEOD-78701-analytics.tsv.undecorated	Tabular
	E-GEOD-78701-analytics.tsv.undecorated.unrounded	Tabular
	E-GEOD-78701-analytics.tsv.unrounded	Tabular

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Estrogen and mTORC1 dependent genes in the uterus of uterine-specific Tsc2-null mice

Project description:To uncover genes regulated by mTORC1 and estradiol in uterine Tsc2-null LAM like cells, we performed RNAseq on uteri from 12-week old wild-type (WT) and uterine-specific Tsc2-null (KO) mice that were either untreated (intact), oopherectomized (ovx) or oopherectomized + treated with 17Î²-estradiol pellets (E2) for 8 weeks. We identified genes that were both estradiol- and TSC2-mediated. Uterine mRNA profiles of 12 week old wild type (WT) and uterine-specific Tsc2-null (KO) mice in the presence or absence of estradiol were generated using Illumina HiSeq2500

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