Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MEXP-1005

ABSTRACT: Transcription profiling by array of brains from mice infected with scrapie ME7

PROVIDER: E-MEXP-1005 | ExpressionAtlas | 2014-09-02

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MEXP-1005-analysis-methods.tsv	Tabular
	E-MEXP-1005-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-1005-configuration.xml	Xml
	E-MEXP-1005-percentile-ranks.tsv	Tabular
	E-MEXP-1005.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 144

Similar Datasets

VLA lyssavirus genotyping dataset

2009-06-09 | GSE14705 | GEO

Project description:JEV infected mice brains global transcriptome

| PRJNA1001148 | ENA

VLA lyssavirus genotyping dataset

Project description:Data from the VLA lyssavirus genotyping microarray. The array platform for this data is GEO accession GPL8066, and consists of 624 oligos representing two viral families. The data set itself consists of 14 arrays, 7 hybridised with RNA from mice brains infected with 7 genotypes of lyssaviruses, 1 hybridised with RNA from normal mouse brain, and 6 hybridised with RNA from coded samples consisting of infected mouse brains or control mouse brains. Keywords: Lyssavirus genotyping microarray Data from the VLA lyssavirus genotyping microarray. The array platform for this data is GEO accession GPL8066, and consists of 624 oligos representing two viral families. The data set itself consists of 14 arrays, 7 hybridised with RNA from mice brains infected with 7 genotypes of lyssaviruses, 1 hybridised with RNA from normal mouse brain, and 6 hybridised with RNA from coded samples consisting of infected mouse brains or control mouse brains. Statistical analysis of the data was done with DetectiV software (Watson et al., 2007). The median and array methods of normalization were used in the statistical analysis of the results. In the median method, DetectiV software calculates the mean fluorescence for each set of probes and normalised against background fluorescence of all probes, assuming that most probes are not hybridized. The array method utilizes an entire control array, e.g. RNA from a known uninfected animal, as the negative control and all probe values are divided by their respective elements from the control array.

2010-05-18 | E-GEOD-14705 | biostudies-arrayexpress

[E-MEXP-3786] IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy

Project description:Transcription profiling by array of mouse male retinas to investigate IGF-I-induced chronic gliosis and retinal stress IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impaired electroretinographic responses at 6-7 months of age that worsen with age. This retinal neuronal dysfunction was correlated with the loss of rod photoreceptors, bipolar, ganglion and amacrines cells. Neuronal alterations were preceded by the overexpression of retinal stress markers, acute phase proteins and gliosis-related genes. IGF-I overexpression leads to chronic gliosis and microgliosis in TgIGF-I retinas, with mild oxidative stress, impaired recycling of glutamate and defective potassium buffering. These impaired supportive functions can contribute to neurodegeneration in TgIGF-I retinas, together with the increased production of pro-inflammatory cytokines, potential mediators of neuronal death.

2013-04-30 | GSE46246 | GEO

Transcriptional profiling of Brucella-infected brains

Project description:Transcriptional profiling of Brucella-infected brains

| PRJNA899110 | ENA

GBS S protein Organs Brain Protoeme Massive Submission

Project description:Quantitative proteome analysis of brains collected from mice infected with GBS

2021-06-02 | MSV000087559 | MassIVE

Transcriptional profiling of Brucella-infected brains

Project description:In order to uncover transcriptional changes occurring in Brucella- infected mouse brains that might lead to neurologic complications, we infected susceptible mice intranasally with Brucella and harvested their brains.

2023-03-17 | GSE217496 | GEO

Project description:JEV infected SIRT2 knockout mice brains global transcriptome

| PRJNA1091868 | ENA

Age- and cell type- specific effects of histone variant H2BE in the brain

Project description:Transcription is regulated in part through histone proteins that bind DNA and control access to genes. Histones can be replaced with variant forms that are particularly critical in the brain and accumulate throughout lifespan. Recent findings defined the first broadly expressed H2B variant, H2BE, and demonstrated that it regulates chromatin structure, neuronal transcription, and mouse behavior. However, the role of H2BE in other cell types and its role throughout lifespan remain unknown. Here, we discovered that H2BE is enriched in astrocytes in the brain and accumulates with age in both astrocytes and neurons. Using single-nucleus RNA-sequencing, we demonstrate that H2BE promotes synaptic gene expression in neurons and astrocytes in young brains. Using microelectrode array recordings, we discovered that H2BE is required in both cell types for proper synaptic function. In aging brains, loss of H2BE similarly affects synaptic genes in neurons but also dampens some age-related transcriptional changes in both astrocytes and neurons. Lastly, behavioral testing demonstrates that H2BE loss disrupts long-term memory but improves working memory in aging mice. Together, these data provide novel links between histone variants, aging-related gene expression changes in both astrocytes and neurons, and memory.

2025-11-09 | PXD069021 | panorama

Quantitative Brain Phosphoproteome Profiling in Bilirubin-Deficient Mice

Project description:Phosphoproteomic profiling of brains from bilirubin-deficient mice

2025-06-05 | PXD064662 |