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E-MTAB-3147

ABSTRACT: Transcription profiling by array of two Caenorhabditis elegans dnj-14 mutant strains compared to two control strains, N2 (Bristol) wild-type and CZ1200

PROVIDER: E-MTAB-3147 | ExpressionAtlas | 2017-02-09

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-3147-analysis-methods.tsv	Tabular
	E-MTAB-3147-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-3147-configuration.xml	Xml
	E-MTAB-3147-percentile-ranks.tsv	Tabular
	E-MTAB-3147.condensed-sdrf.tsv	Tabular

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Project description:Transcriptional profiling of C. elegans strains grown in the presence and absence of ethosuximide. Two mutant alleles of dnj-14 (tm3223 and ok237) and two wild type control strains (N2 and CZ1200) were analysed. dnj-14 is the worm orthologue of the human DNAJC5 gene, mutations in which cause the neurodegenerative disease, adult onset neuronal ceroid lipofucinosis. Ethosuximide ameliorates neurodegenerative phenotypes in the dnj-14 model and also in C. elegans neurodegenerative disease models based on expression of human mutant Tau and TDP-43 proteins. It is hoped that transcriptional profiling of the effect of ethosuximide on gene expression in both wild type and mutant strains might help to identify the mechanism by which ethosuximide exerts its generally neuroprotective mechanism of action. The untreated control samples of this study are also used in the experiment with accession E-MTAB-3147.

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