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E-MTAB-3801

ABSTRACT: Transcription profiling of MCF-7 cells overexpressing phosphodiesterase type 5 (PDE5)

PROVIDER: E-MTAB-3801 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-3801-analysis-methods.tsv	Tabular
	E-MTAB-3801-analytics.tsv	Tabular
	E-MTAB-3801-analytics.tsv.undecorated	Tabular
	E-MTAB-3801-analytics.tsv.undecorated.unrounded	Tabular
	E-MTAB-3801-analytics.tsv.unrounded	Tabular

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Gene expression profiles MCF-10A cells overexpressing MBD2

Project description:Methylated DNA binding protein 2 (MBD2) has been shown to bind specific methylated promoters and suppress transcription. Here we systematically investigate MBD2 suppression by overexpressing MBD2 in MCF-10A cells and generating gene expression profiles of overexpressing cells and normal MCF-10A cells. MCF-10A cells were infected with MBD2 lentivirus in order to increase MBD2 expression. Total RNA was extracted from both infected and non-infected cells and hybridized to Affymetrix gene expression microarrays. Three technical replicates were hybridized for infected and non-infected cells.

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