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E-MTAB-6848

ABSTRACT: Transcription profiling by array to investigate psoriasis risk and non-risk isoforms of CCHCR1 in HEK293 cells

PROVIDER: E-MTAB-6848 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-6848-analysis-methods.tsv	Tabular
	E-MTAB-6848-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-6848-configuration.xml	Xml
	E-MTAB-6848-percentile-ranks.tsv	Tabular
	E-MTAB-6848.condensed-sdrf.tsv	Tabular

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Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes

Project description:CCHCR1 (Coiled-Coil alpha-Helical Rod protein 1) is a putative psoriasis candidate gene with the risk alleles CCHCR1*WWCC and *Iso3, the latter inhibiting the translation of isoform 1. CCHCR1 was recently shown to be a centrosomal protein, as well as a component of cytoplasmic processing bodies (P-bodies) that regulate mRNA turnover. The function of CCHCR1 has remained unsettled, partly because of the inconsistent findings; it has been shown to play a wide variety of roles in divergent processes, e.g., cell proliferation and steroidogenesis. Here we utilized expression microarray and RNA sequencing (RNAseq) using HEK293 cells overexpressing isoforms 1 or 3 (Iso1, Iso3 cells), in combination with the coding non-risk or risk (*WWCC) haplotype of CCHCR1. Our aim was to study the overall role of CCHCR1 and the effects of its variants.

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