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E-MTAB-7079

ABSTRACT: RNA-seq analysis of MES-MM 98 and REN mesothelioma cell lines modulated for miR-24-3p expression

PROVIDER: E-MTAB-7079 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-7079-analysis-methods.tsv	Tabular
	E-MTAB-7079-analytics.tsv	Tabular
	E-MTAB-7079-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-7079-configuration.xml	Xml
	E-MTAB-7079-g2_g1-mvaPlot.png	Other

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RNA-seq analysis of MES-MM 98 and REN mesothelioma cell lines modulated for miR-24-3p expression

Project description:RNA-seq analysis of MES-MM 98 and REN mesothelioma cell lines modulated for miR-24-3p expression

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miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells

Project description:Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance, stable and inducible models of miR-625-3p dysregulation were analyzed. Ectopic expression of miR-625-3p in CRC cells led to increased resistance towards oxPt. The mitogen-activated protein kinase (MAPK) kinase 6 (MAP2K6/MKK6) – an activator of p38 MAPK - was identified as a functional target of miR-625-3p, and, in agreement, was down-regulated in patients not responding to oxPt therapy. The miR-625-3p resistance phenotype could be reversed by anti-miR-625-3p treatment and by ectopic expression of a miR-625-3p insensitive MAP2K6 variant. Transcriptome, proteome and phosphoproteome profiles revealed inactivation of MAP2K6-p38 signaling as a possible driving force behind oxPt resistance. We conclude that miR-625-3p induces oxPt resistance by abrogating MAP2K6-p38 regulated apoptosis and cell cycle control networks.

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Project description:RNA-seq analysis of six cell line models for haematopoiesis: Project 1 of Open Targets - Epigenomes of Cell Lines

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Differentially Expressed Genes in C-33A and CaSki Cells Overexpressing miR-124-3p, miR-23b-3p, or miR-218-5p Modulate Processes and Pathways Involved in Cervical Cancer Progression

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