Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-7302

ABSTRACT: RNA-seq of human midbrain organoid models of Parkinson's Disease

PROVIDER: E-MTAB-7302 | ExpressionAtlas | 2019-01-16

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Similar Datasets

RNA-seq of human midbrain organoid models of Parkinson's Disease

Project description:RNA-seq of human midbrain organoid models of Parkinson's Disease

| PRJEB45026 | ENA

Single cell profile of human iPSC-derived midbrain organoids from healthy individual, Parkinson disease patient harboring a Miro1R272Q mutation and its respective isogenic control

Project description:Midbrain organoids are 3D in vitro models, which represent the human midbrain and can be used as Parkinson's disease (PD) models. In the current study, we used single cell RNA sequencing (scRNA-seq) to investigate the effect of a novel mutation in the RhoT1 gene (Miro1 R272Q) in the PD pathology, and how it affect the dopaminergic neuron population present in the model.

2023-07-31 | GSE237133 | GEO

RNA-Sequencing from ventral mid brain and striatum of paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease.

Project description:We report RNA-sequencing from ventral mid brain and striatum from paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease. We observed several differentially expressed genes upon pesticide exposure which we analyzed by pathway analysis. We examined 3 replicates each for ventral mid brain and striatum per pesticide for RNA-Seq

2012-09-04 | E-GEOD-36232 | biostudies-arrayexpress

Mitochondrial Stress-induced H4K12 Hyperacetylation Dysregulates Transcription in Parkinson's Disease

Project description:Bulk RNA-Seq of littermate controls and Parkinson's disease (PD) transgenic mice models (n=3) The goals of this study are to compare transcriptome profiling (RNA-Seq) in the specific brain region of littermate control and our PD transgenic mice model and look for differential expression genes of interest

2024-04-03 | GSE180408 | GEO

Efavirenz and Fexofenadine ameliorates the propagation of alpha-synuclein

Project description:Current treatments for Parkinson's disease include drug therapy with L-DOPA and MAO-A inhibitors, as well as surgical methods like deep brain stimulation, which can delay disease progression but are not curative. Numerous clinical trials are underway for the development of new drugs, but no approved drugs exist yet. In this study, a list of drugs that included efavirenz and fexofenadine was provided through deep learning. Using these drugs, it was found that they can alleviate the propagation of alpha-synuclein and reduce neuroinflammation in vitro models, in vivo mice, and C.elegans models. RNA-seq and IPA analyses revealed that efavirenz has an effect through the activation of CYP46A1 and the regulation of cholesterol metabolism. also, fexofenadine has an effect inflammation via regulating infiltrated peripheral immune cells. This study not only sheds light on the mechanism of propagation in Parkinson's disease but also suggests the potential use of efavirenz and fexofenadine as a potential treatment for Parkinson's disease through drug repurposing.

2024-02-26 | GSE241257 | GEO

circRNAs in human brains of Parkinson's disease

Project description:total RNA sequencing of Parkinson's disease 3 regions of human brain

2020-06-26 | GSE133101 | GEO

RNA-seq in putamen of Parkinson's disease patients

Project description:RNA-seq in putamen of Parkinson's disease patients

| PRJNA555099 | ENA

RNA-seq in putamen of Parkinson's disease patients

Project description:We performed RNA-seq on total RNA from tissue samples from putamen of the brain from Parkinson's disease patients.

2020-02-01 | GSE134390 | GEO

RNA-Sequencing from ventral mid brain and striatum of paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease.

2012-09-04 | GSE36232 | GEO