Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-7354

ABSTRACT: Transcription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient

PROVIDER: E-MTAB-7354 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-7354-analysis-methods.tsv	Tabular
	E-MTAB-7354-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-7354-configuration.xml	Xml
	E-MTAB-7354-percentile-ranks.tsv	Tabular
	E-MTAB-7354.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 64

Similar Datasets

E-MEXP-3715

Project description:Transcription profiling by array of paired tumour and normal samples from colorectal cancer patients

2025-01-22 | E-MEXP-3715 | ExpressionAtlas

E-GEOD-30448

Project description:Transcriptional effect of an off-target shRNA targeting nucleostemin in human glioblastoma-derived cancer stem cells

2025-01-24 | E-GEOD-30448 | ExpressionAtlas

E-MEXP-3756

Project description:Transcription profiling by array of of peripheral blood cells from 20 healthy controls and 20 colorectal cancer patients

2025-01-22 | E-MEXP-3756 | ExpressionAtlas

E-MTAB-8198

Project description:Functional effect of DOT1L pharmacological inhibition in ER-positive Ovarian Cancer cells

2025-01-16 | E-MTAB-8198 | ExpressionAtlas

E-PROT-6

Project description:Genomic determinants of protein abundance variation in colorectal cancer cells

2021-11-09 | E-PROT-6 | ExpressionAtlas

Identification of hypoxia-induced proteins using SILAC-based proteomics

Project description:A hallmark of solid tumours is the development of hypoxic regions where rapidly growing transformed cells outstrip their blood supply. Tumour cells in these starved regions sense reduced levels of oxygen and switch on genes that help them to adapt, survive and continue growing. Since hypoxia is a key physiological difference between normal and cancer tissue, an opportunity exists to selectively kill tumour cells by exploiting the differences in protein expression between normal and hypoxic tumour tissue. However, a major challenge is to identify druggable hypoxia-induced proteins critical for tumour cell survival. This is especially important in cancers of unmet need where hypoxia gene signatures correlate with poor prognosis (for example, colorectal cancers). To identify new hypoxia-induced proteins, we performed SILAC-based proteomics on colorectal cancer cells exposed to normoxia and hypoxia. In this study, we identify a new hypoxia-activated GPCR signalling axis that enables colorectal tumour cells to survive the microenvironmental stress of hypoxia. Our findings uncover a previously unappreciated role for this GPCR-axis as a key regulator of the adaptive response to hypoxia and highlght an opportunity to exploit tumour-associated hypoxia for therapy.

2018-09-18 | PXD009971 | Pride

Identification of miR-210 target genes in T20 patient-derived sphere culture

Project description:Hypoxia is known to regulate tumor-initiating cells and to have an effect on miRNA expression. We were interested in studying the role of hypoxia-induced miR-210 in colorectal cancer patient-derived sphere cultures. Downregulated genes after overexpression of miR-210 were retained as potential miR-210 target genes for further validation sudies.

2016-10-27 | GSE80236 | GEO

E-MEXP-1194

Project description:Transcription profiling by array of human colorectal cancer epithelial (HCT116) p53 null cells treated with SN38 for 6, 12 and 24h

2025-01-22 | E-MEXP-1194 | ExpressionAtlas

Transcription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient

Project description:Transcriptome profiling of tumour-initiating cells was performed under normoxia and hypoxia conditions for two time points: 3 and 7 days. The cell culture was established from fresh patient material (colorectal tumour) and maintained in spheroid culture condition.

2020-02-01 | E-MTAB-7354 | biostudies-arrayexpress

E-MTAB-6366

Project description:Effect of HE4 overexpression or treatment with recombinant HE4 protein on OVCAR8 ovarian cancer cells

2025-01-23 | E-MTAB-6366 | ExpressionAtlas