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E-MTAB-7435

ABSTRACT: A comparative analysis of the transcriptome profiles of liver and muscle tissue in pigs divergent for feed efficiency

PROVIDER: E-MTAB-7435 | ExpressionAtlas | 2019-05-02

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-7435-analysis-methods.tsv	Tabular
	E-MTAB-7435-analytics.tsv	Tabular
	E-MTAB-7435-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-7435-configuration.xml	Xml
	E-MTAB-7435-g1_g3-mvaPlot.png	Other

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Project description:RNA-seq of muscle from pigs divergent in feed efficiency and product quality

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RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

Project description:Liver is a metabolically complex organ that influences nutrient partitioning and potentially modulates the efficiency of converting energy acquired from macronutrients ingestion into a muscle and/or adipose tissue (referred to as feed efficiency, FE). The objective of this study was to sequence the hepatic tissue transcriptome of pigs divergent for FE and identify relevant biological processes that underpin the differences in liver phenotypes and FE.

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Project description:RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

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Project description:Feed efficiency (FE) is an indicator of efficiency in converting energy from feed into a tissue that is of major environmental and economic significance.This study was to profile the porcine Longissimus thoracis et lumborum (LTL) muscle transcriptome, examine the product quality from pigs divergent in FE and investigate the functional networks underpinning the potential relationship between product quality and FE.

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Project description:Feed efficiency (FE) is an indicator of efficiency in converting energy, attained from macronutrient ingestion, into tissue. Adipose tissue, besides being a master regulator of systemic lipid storage, is also an active endocrine organ that communicates with skeletal muscle, liver and brain to influence appetite, lipid & glucose metabolism and energy homeostasis. Adipose tissue is hypothesised to play a vital part in regulation of FE. The objective of the present study was to sequence the subcutaneous adipose tissue transcriptome in FE-divergent pigs (n=16) and identify relevant biological processes underpinning observed differences in FE.

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