Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-8029

ABSTRACT: RNA-Seq of zebrafish embryos with wdr37 missense variant compared to wild type

PROVIDER: E-MTAB-8029 | ExpressionAtlas | 2019-08-08

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-8029-analysis-methods.tsv	Tabular
	E-MTAB-8029-analytics.tsv	Tabular
	E-MTAB-8029-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-8029-configuration.xml	Xml
	E-MTAB-8029-g2_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 22

Similar Datasets

RNA-Seq of zebrafish embryos with wdr37 missense variant compared to wild type

Project description:RNA-Seq of zebrafish embryos with wdr37 missense variant compared to wild type

| PRJEB32960 | ENA

Proteomic analysis of the secretome of chondrocyte-like cells in Saul-Wilson syndrome

Project description:Saul-Wilson syndrome (SWS) is a rare skeletal dysplasia often presents with features such as a distinct facial phenotype, cataracts, short stature, clubfoot deformities, and microcephaly. We have previously identified that the causative mutation in SWS is a heterozygous, dominant variant (p.G516R) in COG4. COG4 is a Golgi-associated protein which plays important roles in protein trafficking. We further showed that the mutation impacts glycosylation of proteoglycans and disturbs chondrocyte elongation and intercalation in zebrafish embryos expressing COG4p.G516R variant. These effects could be partially rescued by adding wild type cells or their conditioned medium, implicating secretion anomalies associated with COG4p.G516R variant. We have conducted proteomic analysis of the conditioned medium from chondrocyte-like cells (SW1353) expressing COG4p.G516R variant and compared these to wild type SW1353 cells and a knockout of COG4 in these cells. 4,4438 proteins were identified and quantified and comparative analysis was performed. We utilized 3D cultures for performing secretome analysis to investigate the specific changes caused by p.G516R variant compared to WT and COG4-KO.

2023-03-11 | PXD036151 | Pride

Differential Roles of the Maternal and Zygotic FGF in Neural Induction in the Zebrafish Embryo

Project description:Comparison of ATAC-seq and RNA-seq datasets in wild type and SU5402 treated zebrafish embryos

2019-11-29 | GSE90637 | GEO

Differential gene expression in MZudu v. WT zebrafish gastrulae

Project description:We report RNA-sequencing data from zebrafish embryos lacking both maternal and zygotic expression of udu (which encodes Gon4l) (MZudu) at tailbud (TB) stage. Transcripts were compared to stage-matched wild-type (WT) embryos to identify differentially expressed genes.

2017-09-13 | GSE96575 | GEO

Differential gene expression in WT v. MZoep-/- zebrafish gastrulae

Project description:We report RNA-sequencing data from zebrafish embryos lacking both maternal and zygotic expression of oep (which encodes Tdgf1) (MZoep-/-) at 90% epiboly stage. Transcripts were compared to stage-matched wild-type (WT) embryos to identify differentially expressed genes.

2020-05-18 | GSE147302 | GEO

Identification of Strip1-interacting partners in zebrafish head proteome

Project description:Zebrafish embryos expressing GFP-tagged wild type form of Strip1 were used for this study, embryos carrying the GFP-tagged mutant form of Strip1 or GFP only were used as negative controls. Co-immunoprecipitation was performed on 2 dpf head lysates using GFP-trap beads. Samples were prepared for mass spectrometry analysis using trypsin based on-bead digestion protocol.

2022-03-16 | PXD028131 | JPOST Repository

Drop-seq analysis of wild-type (TLAB) zebrafish embryos from high to 6-somite stage (12 timepoints)

Project description:Wild-type zebrafish embryos were mechanically dissociated and profiled using Drop-seq

2018-04-27 | GSE106474 | GEO

Gene expression profiling of MeCP2 deficient zebrafish embryos

Project description:Investigation of whole genome gene expression level changes in mecp2 morphant zebrafish embryos as compared to wild-type strain.

2015-07-21 | GSE71173 | GEO

Expression analysis of zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos

Project description:Investigation of whole genome gene expression level changes in zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos, compared to the wild-type ebryos.

2010-07-13 | GSE20432 | GEO

CellOracle: Dissecting cell identity via network inference and in silico gene perturbation

Project description:Single cell RNA-sequencing analysis of zebrafish embryos with wild type and crispant sample.

2020-02-15 | GSE145298 | GEO