Models

Dataset Information

0

Hornberg2005_ERKcascade


ABSTRACT: SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 Biomodels Curation The model reproduces the time series depicted in Fig 2 of the paper. Also, by varying the values of Vmax for the second kinase (k5) the time series of X3P as shown in Fig3 can be reproduced. The model was successfully tested on MathSBML and Jarnac.

SUBMITTER: Nicolas Le Novère  

PROVIDER: BIOMD0000000084 | BioModels | 2024-09-02

REPOSITORIES: BioModels

altmetric image

Publications

Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control.

Hornberg Jorrit J JJ   Bruggeman Frank J FJ   Binder Bernd B   Geest Christian R CR   de Vaate A J Marjolein Bij AJ   Lankelma Jan J   Heinrich Reinhart R   Westerhoff Hans V HV  

The FEBS journal 20050101 1


General and simple principles are identified that govern signal transduction. The effects of kinase and phosphatase inhibition on a MAP kinase pathway are first examined in silico. Quantitative measures for the control of signal amplitude, duration and integral strength are introduced. We then identify and prove new principles, such that total control on signal amplitude and on final signal strength must amount to zero, and total control on signal duration and on integral signal intensity must e  ...[more]

Similar Datasets

2024-09-02 | BIOMD0000000038 | BioModels
2024-09-02 | BIOMD0000000070 | BioModels
2024-09-02 | BIOMD0000000066 | BioModels
2024-09-02 | BIOMD0000000092 | BioModels
2024-09-02 | BIOMD0000000076 | BioModels
2024-09-02 | BIOMD0000000062 | BioModels
2024-09-02 | BIOMD0000000061 | BioModels
2024-09-02 | BIOMD0000000023 | BioModels
2005-01-01 | MODEL6624199343 | BioModels
2024-09-02 | BIOMD0000000046 | BioModels