Ontology highlight
ABSTRACT:
SUBMITTER: Nicolas Le Novère
PROVIDER: BIOMD0000000084 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 5 1 - 5 of 17 |
Hornberg Jorrit J JJ Bruggeman Frank J FJ Binder Bernd B Geest Christian R CR de Vaate A J Marjolein Bij AJ Lankelma Jan J Heinrich Reinhart R Westerhoff Hans V HV
The FEBS journal 20050101 1
General and simple principles are identified that govern signal transduction. The effects of kinase and phosphatase inhibition on a MAP kinase pathway are first examined in silico. Quantitative measures for the control of signal amplitude, duration and integral strength are introduced. We then identify and prove new principles, such that total control on signal amplitude and on final signal strength must amount to zero, and total control on signal duration and on integral signal intensity must e ...[more]