Ontology highlight
ABSTRACT:
SUBMITTER: Yu-ichi Ozaki
PROVIDER: BIOMD0000000088 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 15 |
Genes to cells : devoted to molecular & cellular mechanisms 20060901 9
Sustained contraction of cells depends on sustained Rho-associated kinase (Rho-kinase) activation. We developed a computational model of the Rho-kinase pathway to understand the systems characteristics. Thrombin-dependent in vivo transient responses of Rho activation and Ca2+ increase could be reproduced in silico. Low and high thrombin stimulation induced transient and sustained phosphorylation, respectively, of myosin light chain (MLC) and myosin phosphatase targeting subunit 1 (MYPT1) in vivo ...[more]