Dataset Information

Somogyi1990_CaOscillations_SingleCaSpike

ABSTRACT: Another model from Hormone induced Calcium Oscillations in Liver Cells Can Be Explained by a Simply One Pool Model. Anatomy of a single Ca2+ spike. Figure4A has been simulated by COPASI4.0.20(development). However, the simulated figure is slightly different from the paper, single spike of Ca2+ is around "6" time arbitrary units instead "9" time arbitrary units displayed in the paper. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Enuo He

PROVIDER: BIOMD0000000115 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

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			Action	DRS
	BIOMD0000000115?filename=BIOMD0000000115-biopax2.owl	Owl
	BIOMD0000000115?filename=BIOMD0000000115-biopax3.owl	Owl
	BIOMD0000000115?filename=BIOMD0000000115-matlab.m	Other
	BIOMD0000000115?filename=BIOMD0000000115-octave.m	Other
	BIOMD0000000115?filename=BIOMD0000000115.m	Other

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Publications

Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model.

Somogyi R R Stucki J W JW

The Journal of biological chemistry 19910601 17

Hormone-induced oscillations of the free intracellular calcium concentration are thought to be relevant for frequency encoding of hormone signals. In liver cells, such Ca2+ oscillations occur in response to stimulation by hormones acting via phosphoinositide breakdown. This observation may be explained by cooperative, positive feedback of Ca2+ on its own release from one inositol 1,4,5-trisphosphate-sensitive pool, obviating oscillations of inositol 1,4,5-trisphosphate. The kinetic rate laws of ...[more]

PMID: 1904060

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