Dataset Information

Eungdamrong2007_Ras_Activation

ABSTRACT: The model reproduces the time profiles of Golgi Ras-GTP and plasma membrane Ras-GTP, subjected to a palmitoylation rate of 0.00015849 second inverse. This is depicted in Fig 5a and 5b for various palmitolylation rates, however the value used in this model is not present in the figure in the paper but corresponds to Fig S2 of the supplement. Model successfully reproduced using MathSBML. Please note that the units of volumetric species in this model are molecules/micrometer cubed, to convert this to microMolar as given in the paper, multiply the simulation result by 1/602. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Harish Dharuri

PROVIDER: BIOMD0000000161 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000161?filename=BIOMD0000000161-biopax2.owl	Owl
	BIOMD0000000161?filename=BIOMD0000000161-biopax3.owl	Owl
	BIOMD0000000161?filename=BIOMD0000000161-matlab.m	Other
	BIOMD0000000161?filename=BIOMD0000000161.m	Other
	BIOMD0000000161?filename=BIOMD0000000161.ode	Other

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Publications

Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi.

Eungdamrong Narat J NJ Iyengar Ravi R

Biophysical journal 20061110 3

Imaging experiments have shown that cell signaling components such as Ras can be activated by growth factors at distinct subcellular locations. Trafficking between these subcellular locations is a regulated dynamic process. The effects of trafficking and the molecular mechanisms underlying compartment-specific Ras activation were studied using numerical simulations of an ordinary differential equation-based multi-compartment model. The simulations show that interplay between two distinct mechani ...[more]

PMID: 17098795

Publication: 1/3

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