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Nazaret2009_TCA_RC_ATP

ABSTRACT: This a model from the article: Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production. Nazaret C, Heiske M, Thurley K, Mazat JP J. Theor. Biol. 2009 Jun;258(3):455-64 19007794 , Abstract: Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.

SUBMITTER: Kieran Smallbone  

PROVIDER: BIOMD0000000232 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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BIOMD0000000232?filename=BIOMD0000000232-biopax2.owl Owl
BIOMD0000000232?filename=BIOMD0000000232-biopax3.owl Owl
BIOMD0000000232?filename=BIOMD0000000232-matlab.m Other
BIOMD0000000232?filename=BIOMD0000000232-octave.m Other
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Publications

Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

Nazaret Christine C   Heiske Margit M   Thurley Kevin K   Mazat Jean-Pierre JP  

Journal of theoretical biology 20081019 3

Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in  ...[more]