Dataset Information

Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin

ABSTRACT: PURPOSE: This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabine or that of its metabolites,n2',2'-difluorodeoxyuridine or gemcitabine triphosphate, are better than gemcitabine dose for prediction of individual response. EXPERIMENTAL DESIGN: Gemcitabine was given thrice weekly on days 1 and 8 in combination with carboplatin, which was given only on day 1 of every cycle. Gemcitabine amount in the body and area under the concentration-time curves of plasma gemcitabine, 2',2'-difluorodeoxyuridine, and intracellular gemcitabine triphosphate in white cells were compared to determine which best describes tumor shrinkage over time. Tumor growth kinetics were described using a Gompertz-like model. RESULTS: The apparent half-life for the effect of gemcitabine was 7.67 weeks. The tumor turnover time constant was 21.8 week.cm. Baseline tumor size and gemcitabine amount in the body to attain 50% of tumor shrinkage were estimated to be 6.66 cm and 10,600 mg. There was no evidence of relapse during treatment.

SUBMITTER: Nick Holford

PROVIDER: BIOMD0000000234 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000234?filename=BIOMD0000000234-biopax2.owl	Owl
	BIOMD0000000234?filename=BIOMD0000000234-biopax3.owl	Owl
	BIOMD0000000234?filename=BIOMD0000000234-matlab.m	Other
	BIOMD0000000234?filename=BIOMD0000000234-octave.m	Other
	BIOMD0000000234?filename=BIOMD0000000234.m	Other

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Publications

A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.

Tham Lai-San LS Wang Lingzhi L Soo Ross A RA Lee Soo-Chin SC Lee How-Sung HS Yong Wei-Peng WP Goh Boon-Cher BC Holford Nicholas H G NH

Clinical cancer research : an official journal of the American Association for Cancer Research 20080701 13

<h4>Purpose</h4>This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabine or that of its metabolites, 2',2'-difluorodeoxyuridine or gemcitabine triphosphate, are better than gemcitabine dose for prediction of individual response.<h4>Experimental design</h4>Gemcitabine was given thrice weekly on days 1 and 8 in combination with carboplatin, which was given only o ...[more]

PMID: 18594002

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