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Panteleev2002_TFPImechanism_schmema1


ABSTRACT: Mikhail A. Panteleev, Veronica I. Zarnitsina & Fazoil I. Ataullakhanov. Tissue factor pathway inhibitor: a possible mechanism of action. European Journal of Biochemistry 269, 8 (2002). We have analyzed several mathematical models that describe inhibition of the factor VIIa-tissue factor complex (VIIa-TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa-TFPI complex is the inhibitor of the extrinsic tenase activity. However, the model based on this hypothesis could not explain well all the available experimental data. Here, we show that a good quantitative description of all experimental data could be achieved in a model that contains two more assumptions. The first assumption is based on the hypothesis originally proposed by Baugh et al. [Baugh, R.J., Broze, G.J. Jr & Krishnaswamy, S. (1998) J. Biol. Chem. 273, 4378-4386], which suggests that TFPI could inhibit the enzyme-product complex Xa-VIIa-TF. The second assumption proposes an interaction between the X-VIIa-TF complex and the factor Xa-TFPI complex. Experiments to test these hypotheses are suggested.

SUBMITTER: Michael Schubert  

PROVIDER: BIOMD0000000361 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Tissue factor pathway inhibitor: a possible mechanism of action.

Panteleev Mikhail A MA   Zarnitsina Veronica I VI   Ataullakhanov Fazoil I FI  

European journal of biochemistry 20020401 8


We have analyzed several mathematical models that describe inhibition of the factor VIIa-tissue factor complex (VIIa-TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa-TFPI complex is the inhibitor of the extrinsic tenase activity. However, the model based on this hypothesis could not explain well all the available experimental data. Here, we show that a good quantitative description of all experimental data  ...[more]

Publication: 1/2

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