Dataset Information

Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease

ABSTRACT: Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease Curated model derived from BIOMD0000000553 This model is described in the article: A positive-feedback model for the loss of acetylcholine in Alzheimer's disease. Ehrenstein G, Galdzicki Z, Lange GD. Ann. N. Y. Acad. Sci. 2000; 899: 283-291 Abstract: We describe a two-component positive-feedback system that could account for the large reduction of acetylcholine that is characteristic of patients with Alzheimer's disease (AD). One component is beta-amyloid-induced apoptosis of cholinergic cells, leading to a decrease in acetylcholine. The other component is an increase in the concentration of beta-amyloid in response to a decrease in acetylcholine. We describe each mechanism with a differential equation, and then solve the two equations numerically. The solution provides a description of the time course of the reduction of acetylcholine in AD patients that is consistent with epidemiological data. This model may also provide an explanation for the significant, but lesser, decrease of other neurotransmitters that is characteristic of AD. This model is hosted on BioModels Database and identified by: BIOMD0000000552. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

DISEASE(S): Alzheimer's Disease

SUBMITTER: Audald Lloret i Villas

PROVIDER: BIOMD0000000552 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000552?filename=BIOMD0000000552-biopax2.owl	Owl
	BIOMD0000000552?filename=BIOMD0000000552-biopax3.owl	Owl
	BIOMD0000000552?filename=BIOMD0000000552-matlab.m	Other
	BIOMD0000000552?filename=BIOMD0000000552-octave.m	Other
	BIOMD0000000552?filename=BIOMD0000000552.m	Other

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A positive-feedback model for the loss of acetylcholine in Alzheimer's disease.

Ehrenstein G G Galdzicki Z Z Lange G D GD

Annals of the New York Academy of Sciences 20000101

We describe a two-component positive-feedback system that could account for the large reduction of acetylcholine that is characteristic of patients with Alzheimer's disease (AD). One component is beta-amyloid-induced apoptosis of cholinergic cells, leading to a decrease in acetylcholine. The other component is an increase in the concentration of beta-amyloid in response to a decrease in acetylcholine. We describe each mechanism with a differential equation, and then solve the two equations numer ...[more]

PMID: 10863547

Publication: 1/2

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