Ontology highlight
ABSTRACT:
DISEASE(S): Clostridium Difficile Colitis
SUBMITTER: Andrew Leber
PROVIDER: BIOMD0000000583 | BioModels | 2024-09-02
REPOSITORIES: BioModels
PloS one 20150731 7
Clostridium difficile infections are associated with the use of broad-spectrum antibiotics and result in an exuberant inflammatory response, leading to nosocomial diarrhea, colitis and even death. To better understand the dynamics of mucosal immunity during C. difficile infection from initiation through expansion to resolution, we built a computational model of the mucosal immune response to the bacterium. The model was calibrated using data from a mouse model of C. difficile infection. The mode ...[more]