Dataset Information

Winter2017 - Brain Energy Metabolism with PPP

ABSTRACT: Winter2017 - Brain Energy Metabolism with PPP This model is described in the article: Mathematical analysis of the influence of brain metabolism on the BOLD signal in Alzheimer's disease Felix Winter1,2, Catrin Bludszuweit-Philipp1 and Olaf Wolkenhauer2,3 Journal of Cerebral Blood Flow & Metabolism Abstract: Blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) is a standard clinical tool for the detection of brain activation. In Alzheimer’s disease (AD), task-related and resting state fMRI have been used to detect brain dysfunction. It has been shown that the shape of the BOLD response is affected in early AD. To correctly interpret these changes, the mechanisms responsible for the observed behaviour need to be known. The parameters of the canonical hemodynamic response function (HRF) commonly used in the analysis of fMRI data have no direct biological interpretation and cannot be used to answer this question. We here present a model that allows relating AD-specific changes in the BOLD shape to changes in the underlying energy metabolism. According to our findings, the classic view that differences in the BOLD shape are only attributed to changes in strength and duration of the stimulus does not hold. Instead, peak height, peak timing and full width at half maximum are sensitive to changes in the reaction rate of several metabolic reactions. Our systems-theoretic approach allows the use of patient-specific clinical data to predict dementia- driven changes in the HRF, which can be used to improve the results of fMRI analyses in AD patients. This model is hosted on BioModels Database and identified by: BIOMD0000000627. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

DISEASE(S): Alzheimer's Disease

SUBMITTER: Felix Winter

PROVIDER: BIOMD0000000627 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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	BIOMD0000000627?filename=BIOMD0000000627-biopax2.owl	Owl
	BIOMD0000000627?filename=BIOMD0000000627-biopax3.owl	Owl
	BIOMD0000000627?filename=BIOMD0000000627.m	Other
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Mathematical analysis of the influence of brain metabolism on the BOLD signal in Alzheimer's disease.

Winter Felix F Bludszuweit-Philipp Catrin C Wolkenhauer Olaf O

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170308 2

Blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) is a standard clinical tool for the detection of brain activation. In Alzheimer's disease (AD), task-related and resting state fMRI have been used to detect brain dysfunction. It has been shown that the shape of the BOLD response is affected in early AD. To correctly interpret these changes, the mechanisms responsible for the observed behaviour need to be known. The parameters of the canonical hemodynamic response fun ...[more]

PMID: 28271954

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