Ontology highlight
ABSTRACT:
SUBMITTER: Matthieu MAIRE
PROVIDER: BIOMD0000000719 | BioModels | 2024-09-02
REPOSITORIES: BioModels
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BIOMD0000000719?filename=Tsai2014.cps | Other | |||
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PLoS biology 20140211 2
During the early development of Xenopus laevis embryos, the first mitotic cell cycle is long (∼85 min) and the subsequent 11 cycles are short (∼30 min) and clock-like. Here we address the question of how the Cdk1 cell cycle oscillator changes between these two modes of operation. We found that the change can be attributed to an alteration in the balance between Wee1/Myt1 and Cdc25. The change in balance converts a circuit that acts like a positive-plus-negative feedback oscillator, with spikes o ...[more]