Ontology highlight
ABSTRACT:
SUBMITTER: Ashley Xavier
PROVIDER: BIOMD0000000720 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 5 1 - 5 of 11 |
Yan Fang F Liu Haihong H Hao Junjun J Liu Zengrong Z
PloS one 20120918 9
MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback loops in the regulation of Rb-E2F pathway are predicted and shown experimentally. Recently, it has been discovered that E2F induce a cluster of miRNAs called miR449. In turn, E2F is inhibited by miR44 ...[more]