Dataset Information

Li2009- Assymetric Caulobacter cell cycle

ABSTRACT: The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alpha-proteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine

SUBMITTER: Ashley Xavier

PROVIDER: BIOMD0000000727 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

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			Action	DRS
	BIOMD0000000727?filename=Li2009-biopax2.owl	Owl
	BIOMD0000000727?filename=Li2009-biopax3.owl	Owl
	BIOMD0000000727?filename=Li2009-matlab.m	Other
	BIOMD0000000727?filename=Li2009.ode	Other
	BIOMD0000000727?filename=Li2009.sedml	Other

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Publications

Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.

Li Shenghua S Brazhnik Paul P Sobral Bruno B Tyson John J JJ

PLoS computational biology 20090814 8

The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in ...[more]

PMID: 19680425

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