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Mouse Iron Distribution - Rich and Deficient iron diets (tracer)


ABSTRACT: Mouse Iron Distribution Dynamics Dynamic model of iron distribution in mice. This model attempts to fit the radioiron tracer data from Lopes et al. 2010 for mice fed iron deficient and rich diets by adjusting the rate of iron intake (vDiet) and the hepcidin synthesis rate (vhepcidin) independently for each experiment. All other parameters are those that provide the best fit for the adequate diet. This model includes the radioiron tracer species. Differences in parameter values between deficient, rich, and adequate diets: Diet vDiet vhepcidin Adequate 0.00377422 1.7393e-08 Deficient 0 8.54927e-09 Rich 0.00415624 2.30942e-08

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: BIOMD0000000734 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Publications

Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient.

Parmar Jignesh H JH   Davis Grey G   Shevchuk Hope H   Mendes Pedro P  

BMC systems biology 20170518 1


<h4>Background</h4>Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative dis  ...[more]

Publication: 1/2

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