Dataset Information

Feizabadi2011/1 - immunodeficiency in cancer core model

ABSTRACT: The paper describes a basic model of immune-cancer interaction. Created by COPASI 4.25 (Build 207) This model is described in the article: Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells Mitra Shojania Feizabadi and Tarynn M. Witten International Journal of Biological Sciences 2011; 7(6):700-707 Abstract: In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotheraputic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Jinghao Men

PROVIDER: BIOMD0000000760 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000760?filename=Feizabadi2011_1.cps	Other
	BIOMD0000000760?filename=Feizabadi2011_1.sedml	Other
	BIOMD0000000760?filename=Feizabadi2011_1.xml	Xml

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Modeling the effects of a simple immune system and immunodeficiency on the dynamics of conjointly growing tumor and normal cells.

Feizabadi Mitra Shojania MS Witten Tarynn M TM

International journal of biological sciences 20110601 6

In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerica ...[more]

PMID: 21647303

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Project description:This ordinary differential equation model of the interactions between tumor and normal cells is based on the publication: S. A. Alharbi and A. S. Rambely, "Dynamic Simulation for Analyzing the Effects of the Intervention of Vitamins on Delaying the Growth of Tumor Cells," in IEEE Access, vol. 7, pp. 128816-128827, 2019 doi: 10.1109/ACCESS.2019.2940060. Comment: This TNM model is described by the system of equations presented in (2), in the publication manuscript. Abstract: The natural sources of the vitamins, which come from a balanced diet (as recommended by the World Cancer Research Fund and the American Institute for Cancer Research) contribute to protecting the body from advancing progressive of cancer stages. Thus, in this study, we analyze the effect of the intervention of vitamins on delaying the growth of cancer cells based on the dynamics of a normal cell cycle when the tumor cells appear in a tissue as a resulting for progressing abnormal cells due to the weak response of the immune system. We developed a mathematical model, called tumor-normal-vitamins model (TNVM), which is governed by a system of ordinary differential equations and refers to two main populations normal cells and tumor cells. This model considers the intervention of vitamins as a moderating factor within thirty days. The models are discussed analytically and numerically by utilizing the Runge-Kutta method to simulate them. The results of the analysis and simulation of free model illustrate that the model will be stable if the tumor cells succeed in eliminating normal cells in the tissue. Whereas, the analysis and simulation of the TNVM showed a case of coexistence between normal cells and tumor cells occur if an individual consumes a regular rate of vitamins that have been simulated to be 87% per day from a natural food source. Even though the response of the immune system is weak, the daily consumption of enough vitamins can play an essential role in delaying the development of an early stage of cancer. This study contributes to the increasing awareness regarding a healthy diet to reduce the risk of some deadly diseases, especially cancer.