Ontology highlight
ABSTRACT:
SUBMITTER: Johannes Meyer
PROVIDER: BIOMD0000000788 | BioModels | 2024-09-02
REPOSITORIES: BioModels
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BIOMD0000000788?filename=Schropp2019.cps | Other | |||
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Schropp Johannes J Khot Antari A Shah Dhaval K DK Koch Gilbert G
CPT: pharmacometrics & systems pharmacology 20190108 3
Bispecific antibodies (BsAbs) bind to two different targets, and create two binary and one ternary complex (TC). These molecules have shown promise as immuno-oncology drugs, and the TC is considered the pharmacologically active species that drives their pharmacodynamic effect. Here, we have presented a general target-mediated drug disposition (TMDD) model for these BsAbs, which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, ...[more]