Dataset Information

Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction

ABSTRACT: This is a mathematical model that describes the interactions between cytotoxic T cells and tumor cells as influenced by B7-H1 (PD-L1) activity, with a focus on how B7-H1 affects cancer cells apoptosis.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000812 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000812?filename=Galante2012.cps	Other
	BIOMD0000000812?filename=Galante2012.sedml	Other
	BIOMD0000000812?filename=Galante2012.xml	Xml

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Publications

B7-h1 and a mathematical model for cytotoxic T cell and tumor cell interaction.

Galante Amanda A Tamada Koji K Levy Doron D

Bulletin of mathematical biology 20110609 1

The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7-H1-negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathema ...[more]

PMID: 21656310

Publication: 1/2

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