Dataset Information

Lee2008 - ERK and PI3K signal integration by Myc

ABSTRACT: Mechanisitc model of PI3K and ERK signal integration by Myc. ERK and PI3K regulated Myc satbility by phosphorylating the same. (PMID:18463697)

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: BIOMD0000000818 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000818?filename=Lee2008.cps	Other
	BIOMD0000000818?filename=Lee2008.sedml	Other
	BIOMD0000000818?filename=Lee2008.xml	Xml

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Publications

Sensing and integration of Erk and PI3K signals by Myc.

Lee Tae T Yao Guang G Nevins Joseph J You Lingchong L

PLoS computational biology 20080229 2

The transcription factor Myc plays a central role in regulating cell-fate decisions, including proliferation, growth, and apoptosis. To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated. Recent studies suggest that such control of Myc can be achieved at the post-translational level via protein stability modulation. Myc is regulated by two Ras effector pathways: the extracellular signal-regulated kinase (Erk) and phosphatidylinositol 3-ki ...[more]

PMID: 18463697

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