Varusai2018 - Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR
Ontology highlight
ABSTRACT:
SUBMITTER: 
Johannes Meyer
PROVIDER: BIOMD0000000823 | BioModels | 2024-09-02
REPOSITORIES: BioModels
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Publications
Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.
Varusai Thawfeek M TM Nguyen Lan K LK
Scientific reports 20180112 1
The mechanistic Target of Rapamycin (mTOR) signalling network is an evolutionarily conserved network that controls key cellular processes, including cell growth and metabolism. Consisting of the major kinase complexes mTOR Complex 1 and 2 (mTORC1/2), the mTOR network harbours complex interactions and feedback loops. The DEP domain-containing mTOR-interacting protein (DEPTOR) was recently identified as an endogenous inhibitor of both mTORC1 and 2 through direct interactions, and is in turn degrad ...[more]
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