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Shin2016 - Unveiling Hidden Dynamics of Hippo Signalling


ABSTRACT: This is a mathematical model describing Hippo signalling pathway activity. It includes descriptions of crosstalk with the Akt and ERK MAPK pathways; crosstalk activity is described using complex regulatory mechanisms comprised of competitive protein-protein interactions and phosphorylation mediated feedback loops.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000832 | BioModels | 2024-09-02

REPOSITORIES: BioModels

Dataset's files

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Publications

Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.

Shin Sung-Young SY   Nguyen Lan K LK  

Genes 20160805 8


The Hippo signalling pathway has recently emerged as an important regulator of cell apoptosis and proliferation with significant implications in human diseases. In mammals, the pathway contains the core kinases MST1/2, which phosphorylate and activate LATS1/2 kinases. The pro-apoptotic function of the MST/LATS signalling axis was previously linked to the Akt and ERK MAPK pathways, demonstrating that the Hippo pathway does not act alone but crosstalks with other signalling pathways to coordinate  ...[more]

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