Ontology highlight
ABSTRACT:
SUBMITTER: Shodhan Rao
PROVIDER: BIOMD0000000835 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 5 1 - 5 of 23 |
Rao Shodhan S van der Schaft Arjan A van Eunen Karen K Bakker Barbara M BM Jayawardhana Bayu B
BMC systems biology 20140503
<h4>Background</h4>In this paper we propose a model reduction method for biochemical reaction networks governed by a variety of reversible and irreversible enzyme kinetic rate laws, including reversible Michaelis-Menten and Hill kinetics. The method proceeds by a stepwise reduction in the number of complexes, defined as the left and right-hand sides of the reactions in the network. It is based on the Kron reduction of the weighted Laplacian matrix, which describes the graph structure of the comp ...[more]