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Dudziuk2019 - Biologically sound formal model of Hsp70 heat induction

ABSTRACT: This is a mathematical model of Hsp70 induction. To model heat shock effects, the model incorporates temperature dependencies in transcirption to Hsp70 mRNA and in dissociation of transcriptional complexes, in addition to a formal expression relating temperature to protein denaturation.

SUBMITTER: Grzegorz

PROVIDER: BIOMD0000000843 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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	BIOMD0000000843?filename=Dudziuk2019-biopax2.owl	Owl
	BIOMD0000000843?filename=Dudziuk2019-biopax3.owl	Owl
	BIOMD0000000843?filename=Dudziuk2019-matlab.m	Other
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	BIOMD0000000843?filename=Dudziuk2019.cps	Other

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Publications

Biologically sound formal model of Hsp70 heat induction.

Dudziuk Grzegorz G Wronowska Weronika W Gambin Anna A Szymańska Zuzanna Z Rybiński Mikołaj M

Journal of theoretical biology 20190608

A proper response to rapid environmental changes is essential for cell survival and requires efficient modifications in the pattern of gene expression. In this respect, a prominent example is Hsp70, a chaperone protein whose synthesis is dynamically regulated in stress conditions. In this paper, we expand a formal model of Hsp70 heat induction originally proposed in previous articles. To accurately capture various modes of heat shock effects, we not only introduce temperature dependencies in tra ...[more]

PMID: 31181241

Publication: 1/3

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