Dataset Information

Viertel2019 - A Computational model of the mammalian external tufted cell

ABSTRACT: This is a mathematical conductance-based model of the bursting activity in external tufted (ET) cells of the olfactory bulb. The model includes ion-current based descriptions of the mechanisms underlying bursting in ET cells, with facilitation of blocking various currents to characterise bursting behaviour.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000844 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000844?filename=Viertel2019-biopax2.owl	Owl
	BIOMD0000000844?filename=Viertel2019-biopax3.owl	Owl
	BIOMD0000000844?filename=Viertel2019-matlab.m	Other
	BIOMD0000000844?filename=Viertel2019-octave.m	Other
	BIOMD0000000844?filename=Viertel2019.cps	Other

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Publications

A Computational model of the mammalian external tufted cell.

Viertel Ryan R Borisyuk Alla A

Journal of theoretical biology 20181002

We introduce a novel detailed conductance-based model of the bursting activity in external tufted (ET) cells of the olfactory bulb. We investigate the mechanisms underlying their bursting, and make experimentally-testable predictions. The ionic currents included in the model are specific to ET cells, and their kinetic and other parameters are based on experimental recordings. We validate the model by showing that its bursting characteristics under various conditions (e.g. blocking various curren ...[more]

PMID: 30290156

Publication: 1/4

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